Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3354027..3354645 | Replicon | chromosome |
Accession | NZ_CP068706 | ||
Organism | Escherichia coli strain J53-p1-pV-hybrid-1 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | JK375_RS16410 | Protein ID | WP_001291435.1 |
Coordinates | 3354427..3354645 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | JK375_RS16405 | Protein ID | WP_000344800.1 |
Coordinates | 3354027..3354401 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JK375_RS16395 | 3349116..3350309 | + | 1194 | WP_001295324.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
JK375_RS16400 | 3350332..3353481 | + | 3150 | WP_001132469.1 | multidrug efflux RND transporter permease subunit | - |
JK375_RS16405 | 3354027..3354401 | + | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
JK375_RS16410 | 3354427..3354645 | + | 219 | WP_001291435.1 | hemolysin expression modulator Hha | Toxin |
JK375_RS16415 | 3354817..3355368 | + | 552 | WP_000102564.1 | maltose O-acetyltransferase | - |
JK375_RS16420 | 3355484..3355954 | + | 471 | WP_000136192.1 | YlaC family protein | - |
JK375_RS16425 | 3356118..3357668 | + | 1551 | WP_001310610.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
JK375_RS16430 | 3357710..3358063 | - | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
JK375_RS16440 | 3358442..3358753 | + | 312 | WP_000409911.1 | MGMT family protein | - |
JK375_RS16445 | 3358784..3359356 | - | 573 | WP_000779842.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T187643 WP_001291435.1 NZ_CP068706:3354427-3354645 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T187643 NZ_CP089932:c3686775-3686392 [Erwinia tracheiphila]
ATGAAATGGATTAGCGCTCAGGAGGTGATAGCGTTTCATGACCGTCTGCTTACAGCTTTGCCGGGCGTTCAGGGAATGCC
AGAGCCGGGAAGAGCAGAGGCGATCATTTATCGTGTTCAGAACCAGCTTTACTATGAAGGTGTTGAGGATATTCACGAAC
TGGCTGCAATGTATCTTGTCGCTATTTCGCGTGGTCATATCTTCAATGACGGCAATAAGCGAACCGCCTTTTTCGTTGCG
ATGGCTTTTTTAAAGCGCAATGGCATTGATATCCGTGACGAAGGTGATGAACTGGAAGAACTGACGGTATCCGCAGCGAT
GGGGGCAGTAAGCAGCGATGATATTGCTGCTGTTTTGCGCCGATTATCCATCAATCCCCACTAA
ATGAAATGGATTAGCGCTCAGGAGGTGATAGCGTTTCATGACCGTCTGCTTACAGCTTTGCCGGGCGTTCAGGGAATGCC
AGAGCCGGGAAGAGCAGAGGCGATCATTTATCGTGTTCAGAACCAGCTTTACTATGAAGGTGTTGAGGATATTCACGAAC
TGGCTGCAATGTATCTTGTCGCTATTTCGCGTGGTCATATCTTCAATGACGGCAATAAGCGAACCGCCTTTTTCGTTGCG
ATGGCTTTTTTAAAGCGCAATGGCATTGATATCCGTGACGAAGGTGATGAACTGGAAGAACTGACGGTATCCGCAGCGAT
GGGGGCAGTAAGCAGCGATGATATTGCTGCTGTTTTGCGCCGATTATCCATCAATCCCCACTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT187643 WP_000344800.1 NZ_CP068706:3354027-3354401 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT187643 NZ_CP089932:c3686993-3686772 [Erwinia tracheiphila]
ATGCGAACCTATACCACATCTCAGGCCCGGCAAAATATTGCCGAAGTAATGGAAGCGGCTACGGCTGGTGAGCCTGTAGA
AATAACTCGCCGCGATGGCTCTGCCGCTGTGCTTATCAGCCGAGATGATTTCAACGCGTGGCAGGAAGCAAAGCTGGATG
CTGAATTTGCCGAAATTATGGGGCGACACGGTCGTACCATTAAGGCGCTGGCCGACAGATGA
ATGCGAACCTATACCACATCTCAGGCCCGGCAAAATATTGCCGAAGTAATGGAAGCGGCTACGGCTGGTGAGCCTGTAGA
AATAACTCGCCGCGATGGCTCTGCCGCTGTGCTTATCAGCCGAGATGATTTCAACGCGTGGCAGGAAGCAAAGCTGGATG
CTGAATTTGCCGAAATTATGGGGCGACACGGTCGTACCATTAAGGCGCTGGCCGACAGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |