Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2192426..2194014 Replicon chromosome
Accession NZ_CP068706
Organism Escherichia coli strain J53-p1-pV-hybrid-1

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag JK375_RS10675 Protein ID WP_001125439.1
Coordinates 2192692..2194014 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JK375_RS10670 Protein ID WP_001301023.1
Coordinates 2192426..2192692 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK375_RS10665 2190803..2191543 + 741 Protein_2085 autotransporter outer membrane beta-barrel domain-containing protein -
JK375_RS10670 2192426..2192692 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JK375_RS10675 2192692..2194014 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
JK375_RS10680 2194326..2194534 + 209 Protein_2088 helix-turn-helix transcriptional regulator -
JK375_RS10685 2194789..2196015 + 1227 Protein_2089 fimbrial biogenesis outer membrane usher protein -
JK375_RS10690 2196029..2196559 + 531 WP_000876763.1 type 1 fimbrial protein -
JK375_RS10695 2196572..2197075 + 504 WP_000825452.1 type 1 fimbrial protein -
JK375_RS10700 2197134..2198048 + 915 WP_000520676.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T187641 WP_001125439.1 NZ_CP068706:2192692-2194014 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T187641 NZ_CP089932:c2858937-2858737 [Erwinia tracheiphila]
ATCAGTAAGCTCAAAACTCTGATGACACTCCTGATTAATGGCAGCTTACCGCTTCCGGCAGAATACAAAGACCATCCGTT
ACAGGGTAATTACAAAGGTTACAGGGACGCTCATATTGAGCCTGACTGGTTACTGATTTATAAAATCACTGACAATCTGC
TTCGCTTTGAACGAACAGGAACGCATTCTGACCTGTTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT187641 WP_001301023.1 NZ_CP068706:2192426-2192692 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT187641 NZ_CP089932:c2859282-2859022 [Erwinia tracheiphila]
ATGGCCGCAAATGCATTAGTCCGTGCGCGTATAGACGAAACATTAAAAAAAGAAGCTGCTGATGTTCTTGCAGGAATGGG
CTTAACCGTGTCCGATCTGGTTCGCATCACTTTAACTAAGGTGGCCAGAGAGAAGGCGTTACCGTTTGATCTGCGCATCC
CTAACGAAGTCACAGCAAACACCATCACGGCCAGTGAAAAAGGCGTTGATGTGCATCAAGCTAAAAATGCAGACGATCTC
TTTGACAAACTGGGCATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References