187640

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2138996..2139522 Replicon chromosome
Accession NZ_CP068706
Organism Escherichia coli strain J53-p1-pV-hybrid-1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JK375_RS10360 Protein ID WP_000323025.1
Coordinates 2139235..2139522 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JK375_RS10355 Protein ID WP_000534858.1
Coordinates 2138996..2139235 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK375_RS10300 2134023..2134790 - 768 Protein_2012 exonuclease -
JK375_RS10305 2134883..2135074 - 192 WP_001083297.1 lysis protein YdfD -
JK375_RS10310 2135071..2135259 - 189 WP_000854559.1 cell division inhibition protein DicB -
JK375_RS10315 2135827..2136045 - 219 WP_001171942.1 hypothetical protein -
JK375_RS10320 2136205..2136360 - 156 WP_000379575.1 DUF1391 family protein -
JK375_RS10325 2136527..2136934 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
JK375_RS10330 2137018..2137248 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
JK375_RS10335 2137232..2137510 + 279 Protein_2019 hypothetical protein -
JK375_RS10340 2137545..2137694 + 150 WP_011443592.1 hypothetical protein -
JK375_RS10345 2138131..2138463 - 333 WP_001301033.1 protein FlxA -
JK375_RS10350 2138666..2138971 - 306 WP_001326990.1 hypothetical protein -
JK375_RS10355 2138996..2139235 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JK375_RS10360 2139235..2139522 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JK375_RS10365 2139594..2139749 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
JK375_RS10370 2139966..2140217 + 252 WP_000980994.1 hypothetical protein -
JK375_RS10375 2140284..2140562 + 279 WP_012304870.1 hypothetical protein -
JK375_RS10380 2140564..2141613 + 1050 WP_001265198.1 DUF968 domain-containing protein -
JK375_RS10385 2141627..2142379 + 753 WP_001047135.1 antitermination protein -
JK375_RS10390 2142657..2142746 - 90 WP_120795389.1 hypothetical protein -
JK375_RS10395 2142801..2143013 - 213 WP_000087756.1 cold shock-like protein CspF -
JK375_RS10400 2143314..2143529 + 216 WP_000066484.1 cold shock-like protein CspB -
JK375_RS10405 2144283..2144498 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2127375..2160763 33388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T187640 WP_000323025.1 NZ_CP068706:2139235-2139522 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T187640 NZ_CP089932:2185591-2185680 [Erwinia tracheiphila]
AAGCCTGCATTAATGCCAACTTTTAGCGCATGGCTCTGAACAGAGCCATTTCCCTGGACTGAAGACAGGAGTTGTCTTCA
GTCTTTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT187640 WP_000534858.1 NZ_CP068706:2138996-2139235 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT187640 NZ_CP089932:c2185681-2185591 [Erwinia tracheiphila]
TAAAAAAAGACTGAAGACAACTCCTGTCTTCAGTCCAGGGAAATGGCTCTGTTCAGAGCCATGCGCTAAAAGTTGGCATT
AATGCAGGCTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References