Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 56156..56681 | Replicon | plasmid unnamed |
| Accession | NZ_CP068697 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain NCCP16345 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | JKV46_RS24295 | Protein ID | WP_001159863.1 |
| Coordinates | 56376..56681 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | JKV46_RS24290 | Protein ID | WP_000813641.1 |
| Coordinates | 56156..56374 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JKV46_RS24260 (JKV46_24135) | 51443..51824 | + | 382 | Protein_61 | YgiW/YdeI family stress tolerance OB fold protein | - |
| JKV46_RS24265 (JKV46_24140) | 51993..52437 | + | 445 | Protein_62 | tyrosine-type recombinase/integrase | - |
| JKV46_RS24270 (JKV46_24145) | 52696..53685 | - | 990 | WP_001527061.1 | RepB family plasmid replication initiator protein | - |
| JKV46_RS24275 (JKV46_24150) | 54179..54475 | - | 297 | WP_001687482.1 | hypothetical protein | - |
| JKV46_RS24280 | 54487..54915 | + | 429 | Protein_65 | hypothetical protein | - |
| JKV46_RS24285 (JKV46_24155) | 54959..55480 | - | 522 | WP_010999942.1 | hypothetical protein | - |
| JKV46_RS24290 (JKV46_24160) | 56156..56374 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| JKV46_RS24295 (JKV46_24165) | 56376..56681 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| JKV46_RS24300 (JKV46_24170) | 56683..56973 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| JKV46_RS24305 (JKV46_24175) | 56970..57491 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| JKV46_RS24310 (JKV46_24180) | 57526..58308 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| JKV46_RS24315 (JKV46_24185) | 58317..58868 | + | 552 | WP_000545754.1 | EAL domain-containing protein | - |
| JKV46_RS24320 (JKV46_24190) | 59055..59543 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| JKV46_RS24325 (JKV46_24195) | 59537..60022 | + | 486 | WP_000905606.1 | membrane protein | - |
| JKV46_RS24330 (JKV46_24200) | 60299..60586 | - | 288 | WP_071530243.1 | hypothetical protein | - |
| JKV46_RS24335 (JKV46_24205) | 60742..61302 | + | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | rck / pefD / pefC / pefA / pefB / fdeC / spvC / spvB | 1..93874 | 93874 | |
| - | flank | IS/Tn | - | - | 61369..61719 | 350 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T187622 WP_001159863.1 NZ_CP068697:56376-56681 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T187622 NZ_CP089927:c3975779-3975366 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT187622 WP_000813641.1 NZ_CP068697:56156-56374 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT187622 NZ_CP089927:c3976042-3975776 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |