Detailed information of TA system TA187621

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 28697..29322
• Replicon: plasmid unnamed
• Accession: NZ_CP068697
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain NCCP16345

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JKV46_RS24135
• Protein ID: WP_000911322.1
• Coordinates: 28697..29095 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JKV46_RS24140
• Protein ID: WP_000450265.1
• Coordinates: 29095..29322 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JKV46_RS24120 (JKV46_23995)	24888..25382	+	495	WP_010999946.1	entry exclusion protein	-
JKV46_RS24125 (JKV46_24000)	25418..26149	+	732	WP_000782438.1	conjugal transfer complement resistance protein TraT	-
JKV46_RS24130 (JKV46_24005)	26526..28688	+	2163	WP_000009318.1	type IV conjugative transfer system coupling protein TraD	-
JKV46_RS24135 (JKV46_24010)	28697..29095	-	399	WP_000911322.1	type II toxin-antitoxin system VapC family toxin	Toxin
JKV46_RS24140 (JKV46_24015)	29095..29322	-	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	rck / pefD / pefC / pefA / pefB / fdeC / spvC / spvB	1..93874	93874

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14887.13 Da
• Isoelectric Point: 8.5264

>T187621 WP_000911322.1 NZ_CP068697:c29095-28697 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDTPAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVGGLRTEDWS

Nucleotide

• Length: 399 bp

>T187621 NZ_CP089927:c3780652-3780059 [Mycobacterium tuberculosis]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8509.49 Da
• Isoelectric Point: 4.5358

>AT187621 WP_000450265.1 NZ_CP068697:c29322-29095 [Salmonella enterica subsp. enterica serovar Typhimurium]
METSVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGESWDEWFDGNNVSADFMDNREQPSVQERESF

Nucleotide

• Length: 228 bp

>AT187621 NZ_CP089927:c3781070-3780681 [Mycobacterium tuberculosis]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA