Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4817389..4818170 Replicon chromosome
Accession NZ_CP068696
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain NCCP16345

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag JKV46_RS23650 Protein ID WP_000626099.1
Coordinates 4817389..4817880 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag JKV46_RS23655 Protein ID WP_001110452.1
Coordinates 4817877..4818170 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKV46_RS23610 (4813384) 4813384..4813959 + 576 WP_001188509.1 transcriptional regulator -
JKV46_RS23620 (4814230) 4814230..4814307 - 78 Protein_4604 helix-turn-helix domain-containing protein -
JKV46_RS23625 (4814398) 4814398..4814730 - 333 WP_001165471.1 MerR family transcriptional regulator -
JKV46_RS23630 (4814802) 4814802..4815179 + 378 WP_000916345.1 EthD family reductase -
JKV46_RS23635 (4816212) 4816212..4816286 + 75 Protein_4607 porin family protein -
JKV46_RS23640 (4816389) 4816389..4817141 + 753 WP_000842434.1 non-specific acid phosphatase -
JKV46_RS23645 (4817288) 4817288..4817341 - 54 WP_231236156.1 SdiA-regulated domain-containing protein -
JKV46_RS23650 (4817389) 4817389..4817880 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
JKV46_RS23655 (4817877) 4817877..4818170 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
JKV46_RS23660 (4818487) 4818487..4818708 + 222 WP_001576552.1 hypothetical protein -
JKV46_RS23665 (4818973) 4818973..4819848 + 876 WP_000921674.1 AraC family transcriptional regulator -
JKV46_RS23670 (4819845) 4819845..4820132 + 288 WP_001269916.1 transcriptional regulator RtsB -
JKV46_RS23675 (4820155) 4820155..4820370 + 216 WP_001595136.1 hypothetical protein -
JKV46_RS23680 (4820378) 4820378..4820647 + 270 WP_010989096.1 hypothetical protein -
JKV46_RS23685 (4820941) 4820941..4821846 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T187620 WP_000626099.1 NZ_CP068696:c4817880-4817389 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T187620 NZ_CP089927:3699892-3700317 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT187620 WP_001110452.1 NZ_CP068696:c4818170-4817877 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT187620 NZ_CP089927:3699674-3699895 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References