Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3981363..3981983 Replicon chromosome
Accession NZ_CP068696
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain NCCP16345

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JKV46_RS19750 Protein ID WP_001280991.1
Coordinates 3981765..3981983 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag JKV46_RS19745 Protein ID WP_000344807.1
Coordinates 3981363..3981737 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKV46_RS19735 (3976502) 3976502..3977695 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JKV46_RS19740 (3977718) 3977718..3980867 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
JKV46_RS19745 (3981363) 3981363..3981737 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
JKV46_RS19750 (3981765) 3981765..3981983 + 219 WP_001280991.1 HHA domain-containing protein Toxin
JKV46_RS19755 (3982162) 3982162..3982713 + 552 WP_001278792.1 maltose O-acetyltransferase -
JKV46_RS19760 (3982830) 3982830..3983300 + 471 WP_000136181.1 YlaC family protein -
JKV46_RS19765 (3983356) 3983356..3983496 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
JKV46_RS19770 (3983502) 3983502..3983762 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
JKV46_RS19775 (3983987) 3983987..3985537 + 1551 WP_000213139.1 EAL domain-containing protein -
JKV46_RS19785 (3985768) 3985768..3986157 + 390 WP_000961285.1 MGMT family protein -
JKV46_RS19790 (3986190) 3986190..3986759 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T187614 WP_001280991.1 NZ_CP068696:3981765-3981983 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T187614 NZ_CP089927:2697731-2697988 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT187614 WP_000344807.1 NZ_CP068696:3981363-3981737 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT187614 NZ_CP089927:2697459-2697734 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References