Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4882374..4882890 Replicon chromosome
Accession NZ_CP068689
Organism Klebsiella pneumoniae subsp. pneumoniae strain RJBSI76

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag I5002_RS24140 Protein ID WP_002886902.1
Coordinates 4882374..4882658 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I5002_RS24145 Protein ID WP_002886901.1
Coordinates 4882648..4882890 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5002_RS24115 4877858..4878166 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
I5002_RS24120 4878251..4878424 + 174 WP_002886906.1 hypothetical protein -
I5002_RS24125 4878427..4879170 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I5002_RS24130 4879527..4881665 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
I5002_RS24135 4881906..4882370 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I5002_RS24140 4882374..4882658 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5002_RS24145 4882648..4882890 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I5002_RS24150 4882968..4884878 - 1911 WP_004152270.1 BglG family transcription antiterminator -
I5002_RS24155 4884901..4886055 - 1155 WP_002886900.1 lactonase family protein -
I5002_RS24160 4886121..4886861 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T187579 WP_002886902.1 NZ_CP068689:c4882658-4882374 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T187579 NZ_CP089927:165037-165411 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT187579 WP_002886901.1 NZ_CP068689:c4882890-4882648 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT187579 NZ_CP089927:164843-165040 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References