Detailed information of TA system TA187527

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2327628..2328105
• Replicon: chromosome
• Accession: NZ_CP068682
• Organism: Staphylococcus aureus strain NCCP11854

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: JKV48_RS11405
• Protein ID: WP_000052076.1
• Coordinates: 2327917..2328105 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: JKV48_RS11400
• Protein ID: WP_001059690.1
• Coordinates: 2327628..2327888 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JKV48_RS11365 (JKV48_11310)	2323020..2323736	-	717	WP_000150029.1	type I 3-dehydroquinate dehydratase	-
JKV48_RS11370 (JKV48_11315)	2323884..2324306	+	423	WP_000974455.1	organic hydroperoxide resistance protein	-
JKV48_RS11375 (JKV48_11320)	2324705..2325199	+	495	WP_000569881.1	GNAT family N-acetyltransferase	-
JKV48_RS11380 (JKV48_11325)	2325355..2325972	+	618	WP_000255554.1	LysE/ArgO family amino acid transporter	-
JKV48_RS11385 (JKV48_11330)	2326045..2326626	-	582	WP_001140697.1	histidine phosphatase family protein	-
JKV48_RS11390 (JKV48_11335)	2326851..2327087	+	237	WP_000368687.1	hypothetical protein	-
JKV48_RS11395 (JKV48_11340)	2327084..2327287	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
JKV48_RS11400 (JKV48_11345)	2327628..2327888	+	261	WP_001059690.1	hypothetical protein	Antitoxin
JKV48_RS11405 (JKV48_11350)	2327917..2328105	+	189	WP_000052076.1	hypothetical protein	Toxin
JKV48_RS11410 (JKV48_11355)	2328293..2328862	+	570	WP_001106657.1	lipoprotein N-acylation protein LnsA	-
JKV48_RS11415 (JKV48_11360)	2328950..2329234	+	285	WP_001004397.1	hypothetical protein	-
JKV48_RS11420 (JKV48_11365)	2329296..2329514	+	219	WP_000005888.1	hypothetical protein	-
JKV48_RS11425 (JKV48_11370)	2330013..2330213	-	201	WP_001059082.1	cold-shock protein	-
JKV48_RS11430 (JKV48_11375)	2330570..2331256	-	687	WP_001823812.1	thermonuclease family protein	-
JKV48_RS11435 (JKV48_11380)	2331597..2332067	-	471	WP_000824462.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-112)

Antitoxin

• Predicted DNA-binding protein, ribbon-helix-helix domain (16-47)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T187527 WP_000052076.1 NZ_CP068682:2327917-2328105 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T187527 NZ_CP089880:c5066036-5065653 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGCCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT187527 WP_001059690.1 NZ_CP068682:2327628-2327888 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT187527 NZ_CP089880:c5066278-5066036 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56