Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1115138..1115652 Replicon chromosome
Accession NZ_CP068682
Organism Staphylococcus aureus strain NCCP11854

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JKV48_RS05460 Protein ID WP_000581792.1
Coordinates 1115443..1115652 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag JKV48_RS05455 Protein ID WP_000138934.1
Coordinates 1115138..1115431 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKV48_RS05435 (JKV48_05400) 1110399..1111040 + 642 WP_000483147.1 thiamine phosphate synthase -
JKV48_RS05440 (JKV48_05405) 1111126..1111998 + 873 WP_000725802.1 membrane protein insertase YidC -
JKV48_RS05445 (JKV48_05410) 1112813..1113460 - 648 WP_001187610.1 HD domain-containing protein -
JKV48_RS05450 (JKV48_05415) 1113488..1114972 - 1485 WP_000571549.1 cardiolipin synthase -
JKV48_RS05455 (JKV48_05420) 1115138..1115431 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
JKV48_RS05460 (JKV48_05425) 1115443..1115652 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JKV48_RS05465 (JKV48_05430) 1115780..1115917 + 138 WP_000828354.1 Lmo0850 family protein -
JKV48_RS05470 (JKV48_05435) 1116181..1117383 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
JKV48_RS05475 (JKV48_05440) 1117701..1118771 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
JKV48_RS05480 (JKV48_05445) 1118786..1120144 + 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T187524 WP_000581792.1 NZ_CP068682:1115443-1115652 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T187524 NZ_CP089880:c4504419-4504099 [Klebsiella pneumoniae]
ATGCACATTTCAACTGTACCGGCCAAGGTGCCGGTTTCGTCACGTCTGTCGCCCGTGCAGGTCTGGCAGCAACTTTTAAC
GTATCTGCTGGGTCACCATTACGGCCTGACGCTTAACGACACACCATTCCATGACGACGCGGCCATCGAAGAGCATATCG
ATGCAGGAATCACGCTCGCCGATGCTGTTAATTTTCTGGTGGAACGTTATGAACTGGTACGCATCGACCGCAAAGGGTTT
AGCTGGCAGGAACAGACTCCGTTCCTGACCGCGACTGATATTCTCCGAGCCAGGCGAGCTACCGGATTAATAAATACTTA
A

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT187524 WP_000138934.1 NZ_CP068682:1115138-1115431 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT187524 NZ_CP089880:c4504779-4504456 [Klebsiella pneumoniae]
ATGTCAATCACACCACCTCATGAATGGGGTCTACAAAGCGATATCACCCCTCGATTTGGCGCTAGATTAGTTCAGGAAGG
CAACCGGCTGTATTACCTGGCTGACAGGGCTGGATTGACGGGAAGTTTTAGCCCAATGCACCTGCAGAAAATAGATCTGG
CTTTCCCGCTGTTTGTCGAACAACTGGAAGATATGCTGCATGCTGGCGAACTAAATCCACATCAGCAATGTCAGGTGAAA
ATTCAACTTGCGAGTTTAACCTGTATAGCTGATACCCGTGGTAGCTGTGGTTACGTTTACATCTCTATTTATCCCAAACC
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References