Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1900385..1901163 Replicon chromosome
Accession NZ_CP068680
Organism Escherichia coli strain NCCP12480

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag JKV47_RS09145 Protein ID WP_000622309.1
Coordinates 1900675..1901163 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A7H9KCB5
Locus tag JKV47_RS09140 Protein ID WP_001110459.1
Coordinates 1900385..1900678 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKV47_RS09115 (1896149) 1896149..1897132 - 984 WP_001325875.1 KpsF/GutQ family sugar-phosphate isomerase -
JKV47_RS09120 (1897633) 1897633..1897893 - 261 WP_001325874.1 hypothetical protein -
JKV47_RS09125 (1897957) 1897957..1898292 - 336 WP_000789899.1 hypothetical protein -
JKV47_RS09130 (1898289) 1898289..1898762 - 474 WP_000143249.1 hypothetical protein -
JKV47_RS09135 (1899355) 1899355..1899851 + 497 Protein_1770 type VI secretion system contractile sheath small subunit -
JKV47_RS09140 (1900385) 1900385..1900678 + 294 WP_001110459.1 DUF1778 domain-containing protein Antitoxin
JKV47_RS09145 (1900675) 1900675..1901163 + 489 WP_000622309.1 GNAT family N-acetyltransferase Toxin
JKV47_RS09150 (1902004) 1902004..1902573 - 570 WP_001290247.1 DUF4942 domain-containing protein -
JKV47_RS09155 (1902670) 1902670..1902867 - 198 WP_000839281.1 DUF957 domain-containing protein -
JKV47_RS09160 (1902879) 1902879..1903367 - 489 WP_000777541.1 DUF5983 family protein -
JKV47_RS09165 (1903364) 1903364..1903738 - 375 WP_000854753.1 TA system toxin CbtA family protein -
JKV47_RS09170 (1903828) 1903828..1904196 - 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA -
JKV47_RS09175 (1904359) 1904359..1904580 - 222 WP_000692303.1 DUF987 domain-containing protein -
JKV47_RS09180 (1904643) 1904643..1905119 - 477 WP_001186710.1 RadC family protein -
JKV47_RS09185 (1905131) 1905131..1905301 - 171 Protein_1780 antirestriction protein -
JKV47_RS09190 (1905302) 1905302..1905532 + 231 Protein_1781 integrase core domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(83-144)

Antitoxin

(14-88)


Sequences


Toxin        


Download         Length: 163 a.a.        Molecular weight: 17491.33 Da        Isoelectric Point: 7.7535

>T187495 WP_000622309.1 NZ_CP068680:1900675-1901163 [Escherichia coli]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSKVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDQSIHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLLVTLGDLV
HA

Download         Length: 489 bp

>T187495 NZ_CP089874:c4543009-4542476 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTATTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 9.9171

>AT187495 WP_001110459.1 NZ_CP068680:1900385-1900678 [Escherichia coli]
MPAANSMAMKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQTFLTRLDQAPAPN
SALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT187495 NZ_CP089874:c4543286-4543020 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7H9KCB5

References