Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 6319708..6321216 Replicon chromosome
Accession NZ_CP068678
Organism Pseudomonas aeruginosa strain NCCP15783

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JKV45_RS29775 Protein ID WP_012613851.1
Coordinates 6320629..6321216 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JKV45_RS29770 Protein ID WP_019726549.1
Coordinates 6319708..6320562 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKV45_RS29755 (JKV45_29775) 6315127..6315336 + 210 WP_003115568.1 cold-shock protein -
JKV45_RS29760 (JKV45_29780) 6315397..6317271 - 1875 WP_019726548.1 MFS transporter -
JKV45_RS29765 (JKV45_29785) 6317446..6319611 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
JKV45_RS29770 (JKV45_29790) 6319708..6320562 - 855 WP_019726549.1 AraC family transcriptional regulator Antitoxin
JKV45_RS29775 (JKV45_29795) 6320629..6321216 - 588 WP_012613851.1 GNAT family protein Toxin
JKV45_RS29780 (JKV45_29800) 6321482..6324961 + 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21929.29 Da        Isoelectric Point: 9.8676

>T187488 WP_012613851.1 NZ_CP068678:c6321216-6320629 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Download         Length: 588 bp

>T187488 NZ_CP089874:325718-326086 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31880.18 Da        Isoelectric Point: 7.1639

>AT187488 WP_019726549.1 NZ_CP068678:c6320562-6319708 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFCHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT187488 NZ_CP089874:325500-325721 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References