Detailed information of TA system TA187486

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 4620045..4621266
• Replicon: chromosome
• Accession: NZ_CP068678
• Organism: Pseudomonas aeruginosa strain NCCP15783

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JKV45_RS21955
• Protein ID: WP_003114949.1
• Coordinates: 4620045..4620623 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JKV45_RS21960
• Protein ID: WP_003088112.1
• Coordinates: 4620712..4621266 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JKV45_RS21940 (JKV45_21955)	4615322..4616599	+	1278	WP_019726104.1	TolC family protein	-
JKV45_RS21945 (JKV45_21960)	4616589..4618760	+	2172	WP_031642042.1	type I secretion system permease/ATPase	-
JKV45_RS21950 (JKV45_21965)	4618750..4619937	+	1188	WP_019726106.1	HlyD family efflux transporter periplasmic adaptor subunit	-
JKV45_RS21955 (JKV45_21970)	4620045..4620623	-	579	WP_003114949.1	HD domain-containing protein	Toxin
JKV45_RS21960 (JKV45_21975)	4620712..4621266	-	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
JKV45_RS21965 (JKV45_21980)	4621424..4623619	-	2196	WP_003450155.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
JKV45_RS21970 (JKV45_21985)	4623624..4624085	-	462	WP_003102736.1	(2Fe-2S)-binding protein	-
JKV45_RS21975 (JKV45_21990)	4624416..4624739	+	324	WP_003102734.1	multidrug efflux SMR transporter	-
JKV45_RS21980 (JKV45_21995)	4624752..4625150	+	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
JKV45_RS21985 (JKV45_22000)	4625147..4625698	-	552	WP_003132721.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21897.75 Da
• Isoelectric Point: 5.3655

>T187486 WP_003114949.1 NZ_CP068678:c4620623-4620045 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Nucleotide

• Length: 579 bp

>T187486 NZ_CP089871:c126506-126024 [Klebsiella pneumoniae]
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTTATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT187486 WP_003088112.1 NZ_CP068678:c4621266-4620712 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT187486 NZ_CP089871:c126760-126494 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA