Detailed information of TA system TA187485

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 3576694..3577952
• Replicon: chromosome
• Accession: NZ_CP068678
• Organism: Pseudomonas aeruginosa strain NCCP15783

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JKV45_RS16810
• Protein ID: WP_019725936.1
• Coordinates: 3577197..3577952 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: JKV45_RS16805
• Protein ID: WP_003086329.1
• Coordinates: 3576694..3577062 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JKV45_RS16785 (JKV45_16795)	3572857..3573132	+	276	WP_010792073.1	zinc ribbon domain-containing protein	-
JKV45_RS16790 (JKV45_16800)	3573135..3573611	-	477	WP_019725934.1	hypothetical protein	-
JKV45_RS16795 (JKV45_16805)	3573690..3575279	+	1590	WP_019725935.1	aldehyde dehydrogenase family protein	-
JKV45_RS16800 (JKV45_16810)	3575335..3576621	+	1287	WP_003163134.1	FAD-binding oxidoreductase	-
JKV45_RS16805 (JKV45_16815)	3576694..3577062	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
JKV45_RS16810 (JKV45_16820)	3577197..3577952	+	756	WP_019725936.1	RES family NAD+ phosphorylase	Toxin
JKV45_RS16815 (JKV45_16825)	3578721..3580082	+	1362	WP_003081943.1	DNA recombination protein RmuC	-
JKV45_RS16820 (JKV45_16830)	3580237..3582780	-	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28192.33 Da
• Isoelectric Point: 8.0554

>T187485 WP_019725936.1 NZ_CP068678:3577197-3577952 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSGHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T187485 NZ_CP089870:c5198470-5198087 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT187485 WP_003086329.1 NZ_CP068678:3576694-3577062 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT187485 NZ_CP089870:c5198712-5198470 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: V6AJU7