Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1898945..1899504 | Replicon | chromosome |
| Accession | NZ_CP068647 | ||
| Organism | Vibrio parahaemolyticus strain TJ-187 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | JHS88_RS08640 | Protein ID | WP_031846599.1 |
| Coordinates | 1899226..1899504 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | JHS88_RS08635 | Protein ID | WP_031846598.1 |
| Coordinates | 1898945..1899229 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JHS88_RS08595 (JHS88_08585) | 1894050..1894130 | - | 81 | WP_078532227.1 | DUF3265 domain-containing protein | - |
| JHS88_RS08600 (JHS88_08590) | 1894145..1894567 | - | 423 | WP_140392184.1 | hypothetical protein | - |
| JHS88_RS08605 (JHS88_08595) | 1894715..1895599 | - | 885 | WP_031778322.1 | hypothetical protein | - |
| JHS88_RS08610 (JHS88_08605) | 1896600..1896767 | - | 168 | WP_162457647.1 | DUF3265 domain-containing protein | - |
| JHS88_RS08615 (JHS88_08610) | 1897040..1897132 | - | 93 | WP_079386106.1 | DUF3265 domain-containing protein | - |
| JHS88_RS08620 (JHS88_08615) | 1897147..1897704 | - | 558 | WP_029857376.1 | hypothetical protein | - |
| JHS88_RS08625 (JHS88_08620) | 1897731..1897823 | - | 93 | WP_072612521.1 | DUF3265 domain-containing protein | - |
| JHS88_RS08630 | 1898291..1898403 | - | 113 | Protein_1670 | DUF3265 domain-containing protein | - |
| JHS88_RS08635 (JHS88_08630) | 1898945..1899229 | + | 285 | WP_031846598.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| JHS88_RS08640 (JHS88_08635) | 1899226..1899504 | + | 279 | WP_031846599.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| JHS88_RS08645 (JHS88_08640) | 1899533..1899625 | - | 93 | WP_079766442.1 | DUF3265 domain-containing protein | - |
| JHS88_RS08650 (JHS88_08645) | 1899640..1899993 | - | 354 | WP_031829440.1 | hypothetical protein | - |
| JHS88_RS08655 (JHS88_08650) | 1900166..1900921 | - | 756 | WP_006741457.1 | DUF3944 domain-containing protein | - |
| JHS88_RS08660 (JHS88_08655) | 1901143..1902762 | - | 1620 | WP_228846245.1 | DUF4263 domain-containing protein | - |
| JHS88_RS08665 (JHS88_08660) | 1902928..1903194 | - | 267 | WP_025527397.1 | barstar family protein | - |
| JHS88_RS08670 (JHS88_08665) | 1903397..1903903 | + | 507 | WP_062905969.1 | hypothetical protein | - |
| JHS88_RS08675 (JHS88_08670) | 1904055..1904273 | - | 219 | WP_031778385.1 | DUF6500 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 1884933..1917100 | 32167 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10935.69 Da Isoelectric Point: 4.3324
>T187476 WP_031846599.1 NZ_CP068647:1899226-1899504 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIVSYWIEGDIIRIM
RVLHQKQKFPMD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIVSYWIEGDIIRIM
RVLHQKQKFPMD
Download Length: 279 bp
>T187476 NZ_CP089870:720871-721356 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11055.37 Da Isoelectric Point: 9.2167
>AT187476 WP_031846598.1 NZ_CP068647:1898945-1899229 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVDHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVDHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT187476 NZ_CP089870:720581-720874 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|