Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 1888392..1888908 | Replicon | chromosome |
| Accession | NZ_CP068647 | ||
| Organism | Vibrio parahaemolyticus strain TJ-187 | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | U2ZZV8 |
| Locus tag | JHS88_RS08545 | Protein ID | WP_005464459.1 |
| Coordinates | 1888392..1888661 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A7W4CB60 |
| Locus tag | JHS88_RS08550 | Protein ID | WP_005483180.1 |
| Coordinates | 1888654..1888908 (-) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JHS88_RS08520 (JHS88_08505) | 1884466..1884899 | - | 434 | Protein_1648 | GNAT family N-acetyltransferase | - |
| JHS88_RS08525 (JHS88_08510) | 1885078..1885488 | - | 411 | WP_024701711.1 | hypothetical protein | - |
| JHS88_RS08530 (JHS88_08515) | 1885569..1886459 | - | 891 | WP_005485669.1 | hypothetical protein | - |
| JHS88_RS08535 (JHS88_08525) | 1887070..1887870 | - | 801 | WP_086482363.1 | IS3 family transposase | - |
| JHS88_RS08540 (JHS88_08530) | 1887867..1888175 | - | 309 | WP_005464425.1 | transposase | - |
| JHS88_RS08545 (JHS88_08535) | 1888392..1888661 | - | 270 | WP_005464459.1 | Txe/YoeB family addiction module toxin | Toxin |
| JHS88_RS08550 (JHS88_08540) | 1888654..1888908 | - | 255 | WP_005483180.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| JHS88_RS08555 (JHS88_08545) | 1889132..1889398 | - | 267 | WP_005464625.1 | hypothetical protein | - |
| JHS88_RS08560 (JHS88_08550) | 1889686..1889841 | - | 156 | Protein_1656 | SDR family oxidoreductase | - |
| JHS88_RS08565 (JHS88_08555) | 1889908..1891058 | + | 1151 | WP_102978303.1 | IS3 family transposase | - |
| JHS88_RS08570 | 1891071..1891379 | - | 309 | WP_025630903.1 | hypothetical protein | - |
| JHS88_RS08575 (JHS88_08565) | 1891764..1891856 | - | 93 | WP_078532240.1 | DUF3265 domain-containing protein | - |
| JHS88_RS08580 (JHS88_08570) | 1891879..1892295 | - | 417 | WP_025507116.1 | hypothetical protein | - |
| JHS88_RS08585 (JHS88_08575) | 1892432..1892920 | - | 489 | WP_031846174.1 | hypothetical protein | - |
| JHS88_RS08590 (JHS88_08580) | 1893049..1893831 | - | 783 | WP_198421245.1 | restriction endonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1875637..1893831 | 18194 | |
| - | inside | Integron | - | - | 1884933..1917100 | 32167 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10614.96 Da Isoelectric Point: 7.9816
>T187475 WP_005464459.1 NZ_CP068647:c1888661-1888392 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY
Download Length: 270 bp
>T187475 NZ_CP089870:350489-350836 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9481.66 Da Isoelectric Point: 5.0623
>AT187475 WP_005483180.1 NZ_CP068647:c1888908-1888654 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE
Download Length: 255 bp
>AT187475 NZ_CP089870:350836-351135 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U2ZZV8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7W4CB60 |