Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1584816..1585363 Replicon chromosome
Accession NZ_CP068641
Organism Vibrio parahaemolyticus strain VP157

Toxin (Protein)


Gene name relE Uniprot ID A0A7Y0S5Y1
Locus tag JHS79_RS08140 Protein ID WP_025796191.1
Coordinates 1585061..1585363 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag JHS79_RS08135 Protein ID WP_005448240.1
Coordinates 1584816..1585073 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHS79_RS08090 (JHS79_07960) 1580348..1580701 + 354 WP_075111209.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
JHS79_RS08095 (JHS79_07965) 1580698..1580808 + 111 WP_171971015.1 DUF3265 domain-containing protein -
JHS79_RS08100 (JHS79_07970) 1581015..1581401 + 387 WP_025523799.1 type II toxin-antitoxin system YafO family toxin -
JHS79_RS08105 (JHS79_07975) 1581401..1581706 + 306 WP_025523800.1 hypothetical protein -
JHS79_RS08110 (JHS79_07980) 1582195..1583345 + 1151 WP_140199405.1 IS3 family transposase -
JHS79_RS08115 (JHS79_07985) 1583568..1584179 + 612 WP_062852697.1 hypothetical protein -
JHS79_RS08120 1584143..1584286 + 144 WP_228770671.1 DUF3265 domain-containing protein -
JHS79_RS08125 (JHS79_07990) 1584312..1584614 + 303 WP_140126675.1 hypothetical protein -
JHS79_RS08130 (JHS79_07995) 1584645..1584734 + 90 WP_074534804.1 DUF3265 domain-containing protein -
JHS79_RS08135 (JHS79_08000) 1584816..1585073 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JHS79_RS08140 (JHS79_08005) 1585061..1585363 + 303 WP_025796191.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHS79_RS08145 (JHS79_08010) 1585399..1585491 + 93 WP_074531687.1 DUF3265 domain-containing protein -
JHS79_RS08150 (JHS79_08015) 1585519..1585905 + 387 WP_025441768.1 hypothetical protein -
JHS79_RS08155 1585952..1586131 + 180 WP_025441769.1 pentapeptide repeat-containing protein -
JHS79_RS08160 (JHS79_08025) 1586125..1586238 + 114 WP_077345981.1 DUF3265 domain-containing protein -
JHS79_RS08165 (JHS79_08030) 1586579..1586704 + 126 WP_079390566.1 DUF3265 domain-containing protein -
JHS79_RS08170 (JHS79_08035) 1586736..1587077 + 342 WP_140126676.1 hypothetical protein -
JHS79_RS08175 (JHS79_08040) 1587251..1587676 + 426 WP_025441771.1 N-acetyltransferase -
JHS79_RS08180 (JHS79_08045) 1587691..1587783 + 93 WP_193238404.1 DUF3265 domain-containing protein -
JHS79_RS08185 1588202..1588331 + 130 Protein_1595 DUF3265 domain-containing protein -
JHS79_RS26865 1588403..1588525 - 123 WP_257790319.1 hypothetical protein -
JHS79_RS08190 (JHS79_08050) 1589311..1589628 - 318 WP_025441772.1 hypothetical protein -
JHS79_RS08195 (JHS79_08055) 1590120..1590299 + 180 WP_025441774.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 1317021..1868049 551028
- inside Integron - - 1435963..1610612 174649


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11655.54 Da        Isoelectric Point: 5.1765

>T187474 WP_025796191.1 NZ_CP068641:1585061-1585363 [Vibrio parahaemolyticus]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T187474 NZ_CP089870:324518-324886 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT187474 WP_005448240.1 NZ_CP068641:1584816-1585073 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT187474 NZ_CP089870:324300-324521 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y0S5Y1

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References