Detailed information of TA system TA187473

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1531895..1532460
• Replicon: chromosome
• Accession: NZ_CP068641
• Organism: Vibrio parahaemolyticus strain VP157

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JHS79_RS07630
• Protein ID: WP_031818843.1
• Coordinates: 1532173..1532460 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: JHS79_RS07625
• Protein ID: WP_000086647.1
• Coordinates: 1531895..1532176 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHS79_RS07575	1527446..1527544	+	99	Protein_1474	DUF3265 domain-containing protein	-
JHS79_RS07580 (JHS79_07485)	1527605..1528189	+	585	WP_237301268.1	PH domain-containing protein	-
JHS79_RS07585 (JHS79_07490)	1528231..1528320	+	90	WP_071881309.1	DUF3265 domain-containing protein	-
JHS79_RS07590 (JHS79_07495)	1528904..1529128	-	225	WP_079765227.1	hypothetical protein	-
JHS79_RS07595	1529299..1529346	+	48	WP_237301321.1	hypothetical protein	-
JHS79_RS07600 (JHS79_07505)	1529376..1529960	+	585	WP_140126758.1	hypothetical protein	-
JHS79_RS07605 (JHS79_07510)	1529987..1530079	+	93	WP_077200619.1	DUF3265 domain-containing protein	-
JHS79_RS07610 (JHS79_07515)	1530113..1530460	+	348	WP_042770024.1	SH3 domain-containing protein	-
JHS79_RS07615 (JHS79_07520)	1530606..1531031	+	426	WP_237301270.1	hypothetical protein	-
JHS79_RS07620 (JHS79_07525)	1531252..1531689	+	438	WP_025611425.1	hypothetical protein	-
JHS79_RS07625 (JHS79_07530)	1531895..1532176	+	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JHS79_RS07630 (JHS79_07535)	1532173..1532460	+	288	WP_031818843.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JHS79_RS07635 (JHS79_07545)	1532608..1533120	+	513	WP_237301272.1	GNAT family N-acetyltransferase	-
JHS79_RS07640 (JHS79_07550)	1533135..1533197	+	63	WP_193235574.1	DUF3265 domain-containing protein	-
JHS79_RS07645 (JHS79_07555)	1533257..1534060	+	804	WP_075111381.1	hypothetical protein	-
JHS79_RS07650	1534042..1534167	+	126	WP_229617493.1	DUF3265 domain-containing protein	-
JHS79_RS07655 (JHS79_07560)	1534230..1534595	+	366	WP_025611610.1	T6SS amidase immunity protein Tai4 family protein	-
JHS79_RS07660 (JHS79_07565)	1534610..1534702	+	93	WP_075111383.1	DUF3265 domain-containing protein	-
JHS79_RS07665 (JHS79_07570)	1534738..1535346	+	609	WP_005500304.1	pyridoxamine 5'-phosphate oxidase family protein	-
JHS79_RS07670 (JHS79_07575)	1535489..1536061	+	573	WP_065771588.1	hypothetical protein	-
JHS79_RS07675 (JHS79_07580)	1536058..1536177	+	120	WP_140126783.1	DUF3265 domain-containing protein	-
JHS79_RS07680 (JHS79_07585)	1536211..1536687	+	477	WP_063517557.1	GNAT family N-acetyltransferase	-
JHS79_RS07685 (JHS79_07590)	1536650..1536793	+	144	WP_079771488.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	VP1611	1317021..1868049	551028
	-	inside	Integron	-	-	1435963..1610612	174649

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11017.72 Da
• Isoelectric Point: 5.6096

>T187473 WP_031818843.1 NZ_CP068641:1532173-1532460 [Vibrio parahaemolyticus]
MKVVWSPLALQKLGDAAEFISLDNPPAAERWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRI
LTVRNCRQILSESDV

Nucleotide

• Length: 288 bp

>T187473 NZ_CP089849:c5436748-5436479 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGGAGCCGTTGC
AGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGATGCGGGTCCC
GAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT187473 WP_000086647.1 NZ_CP068641:1531895-1532176 [Vibrio parahaemolyticus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT187473 NZ_CP089849:c5436467-5436162 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAATGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0