Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 1509856..1510405 Replicon chromosome
Accession NZ_CP068641
Organism Vibrio parahaemolyticus strain VP157

Toxin (Protein)


Gene name parE Uniprot ID A0A854GNW5
Locus tag JHS79_RS07390 Protein ID WP_025527257.1
Coordinates 1509856..1510155 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A347UQT2
Locus tag JHS79_RS07395 Protein ID WP_005442033.1
Coordinates 1510163..1510405 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHS79_RS07340 (JHS79_07270) 1505365..1506027 + 663 WP_140126651.1 hypothetical protein -
JHS79_RS07345 (JHS79_07275) 1506042..1506134 + 93 WP_140126650.1 DUF3265 domain-containing protein -
JHS79_RS07350 (JHS79_07280) 1506174..1506323 + 150 WP_180700319.1 hypothetical protein -
JHS79_RS07355 (JHS79_07290) 1507219..1507506 + 288 WP_237301260.1 hypothetical protein -
JHS79_RS07360 (JHS79_07295) 1507543..1507878 + 336 WP_237301262.1 hypothetical protein -
JHS79_RS07365 (JHS79_07300) 1508039..1508623 + 585 WP_140126648.1 hypothetical protein -
JHS79_RS07370 (JHS79_07305) 1508638..1508730 + 93 WP_193244088.1 DUF3265 domain-containing protein -
JHS79_RS07375 (JHS79_07310) 1508837..1509190 + 354 WP_045603772.1 NUDIX domain-containing protein -
JHS79_RS07380 (JHS79_07315) 1509335..1509664 + 330 WP_140126647.1 hypothetical protein -
JHS79_RS07385 1509664..1509738 + 75 Protein_1436 DUF3265 domain-containing protein -
JHS79_RS07390 (JHS79_07320) 1509856..1510155 - 300 WP_025527257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHS79_RS07395 (JHS79_07325) 1510163..1510405 - 243 WP_005442033.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JHS79_RS07400 1510480..1510554 + 75 Protein_1439 DUF3265 domain-containing protein -
JHS79_RS07405 (JHS79_07330) 1510660..1511013 + 354 WP_102601034.1 DUF6404 family protein -
JHS79_RS07410 1511041..1511134 + 94 Protein_1441 DUF3265 domain-containing protein -
JHS79_RS07415 (JHS79_07335) 1511589..1511681 + 93 WP_080261774.1 DUF3265 domain-containing protein -
JHS79_RS07420 1511926..1512123 + 198 WP_237301263.1 hypothetical protein -
JHS79_RS07425 (JHS79_07340) 1512177..1512265 + 89 Protein_1444 DUF3265 domain-containing protein -
JHS79_RS07430 (JHS79_07345) 1512786..1512929 + 144 WP_219585283.1 DUF3265 domain-containing protein -
JHS79_RS07435 (JHS79_07350) 1512956..1513588 + 633 WP_237301264.1 class I SAM-dependent methyltransferase -
JHS79_RS07440 (JHS79_07355) 1513749..1514576 + 828 WP_140126696.1 restriction endonuclease -
JHS79_RS07445 (JHS79_07360) 1514700..1515188 + 489 WP_045621769.1 hypothetical protein -
JHS79_RS07450 (JHS79_07365) 1515149..1515295 + 147 WP_080608865.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 1317021..1868049 551028
- inside Integron - - 1435963..1610612 174649


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-55)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11573.18 Da        Isoelectric Point: 8.0265

>T187472 WP_025527257.1 NZ_CP068641:c1510155-1509856 [Vibrio parahaemolyticus]
MQKNKYKLSNLAQSHLRKVKDYTVENFSELQWRNYKDTLLSGFQMLADNPDLGRSCDEIYPNGFYFPIGKHTAYFIKEDD
FILVVAVLGQSQLPQNHLK

Download         Length: 300 bp

>T187472 NZ_CP089849:c4460106-4459519 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGACGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGTGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9047.26 Da        Isoelectric Point: 5.6926

>AT187472 WP_005442033.1 NZ_CP068641:c1510405-1510163 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Download         Length: 243 bp

>AT187472 NZ_CP089849:c4459452-4458598 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTAGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTAGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAGCAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTTGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854GNW5

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQT2

References