Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 1445884..1446433 Replicon chromosome
Accession NZ_CP068641
Organism Vibrio parahaemolyticus strain VP157

Toxin (Protein)


Gene name parE Uniprot ID A0A854GNW5
Locus tag JHS79_RS06715 Protein ID WP_025527257.1
Coordinates 1445884..1446183 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A347UQT2
Locus tag JHS79_RS06720 Protein ID WP_005442033.1
Coordinates 1446191..1446433 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHS79_RS06655 (JHS79_06635) 1441159..1441614 + 456 WP_024701707.1 GNAT family N-acetyltransferase -
JHS79_RS06660 (JHS79_06640) 1441611..1441733 + 123 WP_086026910.1 DUF3265 domain-containing protein -
JHS79_RS06665 (JHS79_06645) 1441755..1442156 + 402 WP_180794573.1 HIT family protein -
JHS79_RS06670 (JHS79_06650) 1442191..1442283 + 93 WP_080339230.1 DUF3265 domain-containing protein -
JHS79_RS06675 (JHS79_06655) 1442364..1442777 + 414 WP_237301248.1 hypothetical protein -
JHS79_RS06680 (JHS79_06660) 1443810..1443953 + 144 WP_237301315.1 DUF3265 domain-containing protein -
JHS79_RS06685 (JHS79_06665) 1443982..1444380 + 399 WP_017821406.1 DUF6232 family protein -
JHS79_RS06690 (JHS79_06670) 1444395..1444487 + 93 WP_017821407.1 DUF3265 domain-containing protein -
JHS79_RS06695 (JHS79_06675) 1444563..1444892 + 330 WP_237301249.1 hypothetical protein -
JHS79_RS06700 (JHS79_06680) 1444889..1445005 + 117 WP_237301250.1 DUF3265 domain-containing protein -
JHS79_RS06705 (JHS79_06685) 1445032..1445304 + 273 WP_005462157.1 nicotinamide mononucleotide transporter -
JHS79_RS06710 (JHS79_06690) 1445315..1445425 + 111 WP_080666457.1 DUF3265 domain-containing protein -
JHS79_RS06715 (JHS79_06695) 1445884..1446183 - 300 WP_025527257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHS79_RS06720 (JHS79_06700) 1446191..1446433 - 243 WP_005442033.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JHS79_RS06725 1446508..1446582 + 75 Protein_1307 DUF3265 domain-containing protein -
JHS79_RS06730 (JHS79_06705) 1446676..1447122 + 447 WP_237301252.1 hypothetical protein -
JHS79_RS06735 (JHS79_06710) 1447155..1447247 + 93 WP_193293287.1 DUF3265 domain-containing protein -
JHS79_RS06740 (JHS79_06715) 1447787..1448362 + 576 WP_237301254.1 NAD(P)H-dependent oxidoreductase -
JHS79_RS06745 (JHS79_06720) 1448949..1449026 + 78 WP_079765744.1 DUF3265 domain-containing protein -
JHS79_RS06750 (JHS79_06725) 1449513..1449644 + 132 WP_109170249.1 DUF3265 domain-containing protein -
JHS79_RS06755 (JHS79_06730) 1449672..1450229 + 558 WP_140126713.1 hypothetical protein -
JHS79_RS06760 (JHS79_06735) 1450778..1450900 + 123 WP_078235757.1 DUF3265 domain-containing protein -
JHS79_RS06765 (JHS79_06740) 1450928..1451383 + 456 WP_180700363.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 1317021..1868049 551028
- inside Integron - - 1435963..1610612 174649


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-55)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11573.18 Da        Isoelectric Point: 8.0265

>T187471 WP_025527257.1 NZ_CP068641:c1446183-1445884 [Vibrio parahaemolyticus]
MQKNKYKLSNLAQSHLRKVKDYTVENFSELQWRNYKDTLLSGFQMLADNPDLGRSCDEIYPNGFYFPIGKHTAYFIKEDD
FILVVAVLGQSQLPQNHLK

Download         Length: 300 bp

>T187471 NZ_CP089849:c3003146-3002568 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCACTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9047.26 Da        Isoelectric Point: 5.6926

>AT187471 WP_005442033.1 NZ_CP068641:c1446433-1446191 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Download         Length: 243 bp

>AT187471 NZ_CP089849:c3003788-3003234 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCATCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCTTGCTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCCCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854GNW5

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQT2

References