Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 712941..714769 Replicon chromosome
Accession NZ_CP068641
Organism Vibrio parahaemolyticus strain VP157

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JHS79_RS03305 Protein ID WP_180700443.1
Coordinates 713408..714769 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JHS79_RS03300 Protein ID WP_045604471.1
Coordinates 712941..713423 (-) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHS79_RS03280 (JHS79_03270) 708305..709195 + 891 WP_193283864.1 IS5 family transposase -
JHS79_RS03285 (JHS79_03275) 709429..710214 + 786 WP_257390990.1 AAA family ATPase -
JHS79_RS03290 (JHS79_03280) 710214..711347 + 1134 WP_237301136.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
JHS79_RS03295 (JHS79_03285) 711342..712577 - 1236 Protein_638 integrase domain-containing protein -
JHS79_RS03300 (JHS79_03290) 712941..713423 - 483 WP_045604471.1 helix-turn-helix domain-containing protein Antitoxin
JHS79_RS03305 (JHS79_03295) 713408..714769 - 1362 WP_180700443.1 type II toxin-antitoxin system HipA family toxin Toxin
JHS79_RS03310 (JHS79_03300) 715260..716042 - 783 WP_140125621.1 metallophosphoesterase -
JHS79_RS03315 (JHS79_03305) 716377..716583 + 207 WP_140125622.1 hypothetical protein -
JHS79_RS03320 716804..716962 - 159 Protein_643 tyrosine-type recombinase/integrase -
JHS79_RS03325 717295..717705 + 411 WP_140090046.1 hypothetical protein -
JHS79_RS03330 717677..718027 + 351 WP_229634353.1 AHH domain-containing protein -
JHS79_RS03335 (JHS79_03315) 718027..718602 + 576 WP_025442956.1 hypothetical protein -
JHS79_RS03340 (JHS79_03320) 718911..719570 - 660 WP_031847057.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 704131..738184 34053
- flank IS/Tn - - 708305..709195 890


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-140)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51410.19 Da        Isoelectric Point: 4.8673

>T187470 WP_180700443.1 NZ_CP068641:c714769-713408 [Vibrio parahaemolyticus]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCINLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T187470 NZ_CP089849:2018930-2019685 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGGAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGCCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17564.09 Da        Isoelectric Point: 10.9400

>AT187470 WP_045604471.1 NZ_CP068641:c713423-712941 [Vibrio parahaemolyticus]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTNTTHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp

>AT187470 NZ_CP089849:2018427-2018795 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References