Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1832739..1833298 Replicon chromosome
Accession NZ_CP068638
Organism Vibrio parahaemolyticus strain VP120

Toxin (Protein)


Gene name relE Uniprot ID A0A249W573
Locus tag JHT21_RS08290 Protein ID WP_005500338.1
Coordinates 1833020..1833298 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag JHT21_RS08285 Protein ID WP_005398409.1
Coordinates 1832739..1833023 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHT21_RS08260 (JHT21_08250) 1828384..1828845 - 462 WP_005500350.1 hypothetical protein -
JHT21_RS08265 (JHT21_08255) 1829187..1829633 + 447 WP_021449154.1 DUF3291 domain-containing protein -
JHT21_RS08270 1830186..1830374 - 189 WP_021823297.1 pyridoxamine 5'-phosphate oxidase family protein -
JHT21_RS08280 (JHT21_08270) 1832182..1832472 - 291 WP_005500341.1 YkgJ family cysteine cluster protein -
JHT21_RS08285 (JHT21_08275) 1832739..1833023 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JHT21_RS08290 (JHT21_08280) 1833020..1833298 + 279 WP_005500338.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
JHT21_RS08295 (JHT21_08285) 1833327..1833416 - 90 WP_072828858.1 DUF3265 domain-containing protein -
JHT21_RS08300 (JHT21_08290) 1833434..1833787 - 354 WP_017449619.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
JHT21_RS08305 (JHT21_08295) 1834244..1834312 - 69 WP_074531725.1 DUF3265 domain-containing protein -
JHT21_RS08310 (JHT21_08300) 1834387..1834635 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JHT21_RS08315 (JHT21_08305) 1834625..1834915 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin -
JHT21_RS08320 (JHT21_08310) 1835054..1835413 - 360 WP_029806843.1 hypothetical protein -
JHT21_RS08325 (JHT21_08315) 1835569..1835952 - 384 WP_029806841.1 hypothetical protein -
JHT21_RS08330 (JHT21_08320) 1836108..1836650 - 543 WP_029806840.1 SEC-C metal-binding domain-containing protein -
JHT21_RS08335 (JHT21_08325) 1836725..1836835 - 111 WP_077345731.1 DUF3265 domain-containing protein -
JHT21_RS08340 (JHT21_08330) 1837119..1837208 - 90 WP_077345730.1 DUF3265 domain-containing protein -
JHT21_RS08345 (JHT21_08335) 1837231..1837572 - 342 WP_029807300.1 hypothetical protein -
JHT21_RS08350 1837769..1837957 - 189 Protein_1616 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vpadF 1787820..1874336 86516
- inside Integron - - 1829868..1852111 22243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10878.53 Da        Isoelectric Point: 4.2597

>T187467 WP_005500338.1 NZ_CP068638:1833020-1833298 [Vibrio parahaemolyticus]
MILWEEESLDDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T187467 NZ_CP089849:1678193-1678558 [Pseudomonas aeruginosa]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGGGGGCCATCCTTGGGGCACCCCCACAGCAGCGGCATCAATGGCTCCCGCCATG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGACCCCAGACGCTCCGCG
ATACTGCTGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGAACGTGCCCATTGCCGACCGCCTCTATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT187467 WP_005398409.1 NZ_CP068638:1832739-1833023 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT187467 NZ_CP089849:1678551-1678874 [Pseudomonas aeruginosa]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGCACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGGCTAGAGGTTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCAGGTGC
AGCAGCCGGCAATTGCCAAGATGGAGCGGCGTACGGATATGTACATTTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCAGCTGGAAGTGATTGCACGCTTCCCGGATGGTGCGGTGAAAATCAGCAACTTCGCGGATATCGAAGAGGCAGGCGC
CTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249W573

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References