Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2084533..2085080 Replicon chromosome
Accession NZ_CP068633
Organism Vibrio parahaemolyticus strain VP17

Toxin (Protein)


Gene name relE Uniprot ID A0A7Z2MSV0
Locus tag JHT19_RS09910 Protein ID WP_025527253.1
Coordinates 2084533..2084835 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag JHT19_RS09915 Protein ID WP_005448240.1
Coordinates 2084823..2085080 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHT19_RS09855 (JHT19_09815) 2079680..2079760 - 81 Protein_1915 DUF3265 domain-containing protein -
JHT19_RS09860 (JHT19_09820) 2080399..2080983 - 585 WP_201452316.1 cold shock and DUF1294 domain-containing protein -
JHT19_RS09865 (JHT19_09825) 2081027..2081119 - 93 WP_008081753.1 DUF3265 domain-containing protein -
JHT19_RS09870 (JHT19_09830) 2081140..2081727 - 588 WP_114867662.1 hypothetical protein -
JHT19_RS09875 (JHT19_09835) 2081887..2082237 - 351 WP_042762920.1 RidA family protein -
JHT19_RS09880 (JHT19_09840) 2082386..2082682 - 297 WP_114867663.1 hypothetical protein -
JHT19_RS09885 (JHT19_09845) 2082848..2083252 - 405 WP_021705403.1 DUF1801 domain-containing protein -
JHT19_RS09890 (JHT19_09850) 2083407..2083928 - 522 WP_114867664.1 GNAT family N-acetyltransferase -
JHT19_RS09895 (JHT19_09855) 2083958..2084050 - 93 WP_140341327.1 DUF3265 domain-containing protein -
JHT19_RS09900 (JHT19_09860) 2084076..2084360 - 285 WP_103195693.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
JHT19_RS09905 (JHT19_09865) 2084405..2084497 - 93 WP_080285085.1 DUF3265 domain-containing protein -
JHT19_RS09910 (JHT19_09870) 2084533..2084835 - 303 WP_025527253.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHT19_RS09915 (JHT19_09875) 2084823..2085080 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JHT19_RS09920 (JHT19_09880) 2085162..2085251 - 90 WP_071652537.1 DUF3265 domain-containing protein -
JHT19_RS09925 (JHT19_09885) 2085772..2085861 - 90 WP_079399712.1 DUF3265 domain-containing protein -
JHT19_RS09930 (JHT19_09890) 2085879..2086496 - 618 WP_114867666.1 hypothetical protein -
JHT19_RS09935 (JHT19_09895) 2086519..2086641 - 123 WP_077281732.1 DUF3265 domain-containing protein -
JHT19_RS09940 (JHT19_09900) 2087079..2087630 - 552 WP_114867667.1 VRR-NUC domain-containing protein -
JHT19_RS09945 (JHT19_09905) 2087649..2087780 - 132 WP_114867668.1 DUF3265 domain-containing protein -
JHT19_RS09950 (JHT19_09910) 2088183..2088296 - 114 Protein_1934 DUF3265 domain-containing protein -
JHT19_RS09955 (JHT19_09915) 2088286..2088591 - 306 WP_025787418.1 hypothetical protein -
JHT19_RS09960 (JHT19_09920) 2088663..2088752 - 90 WP_072833118.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 2014345..2097853 83508


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11640.53 Da        Isoelectric Point: 4.8951

>T187465 WP_025527253.1 NZ_CP068633:c2084835-2084533 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T187465 NZ_CP089849:1174544-1174843 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT187465 WP_005448240.1 NZ_CP068633:c2085080-2084823 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT187465 NZ_CP089849:1174840-1175130 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGATAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2MSV0

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References