Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2018045..2018561 Replicon chromosome
Accession NZ_CP068633
Organism Vibrio parahaemolyticus strain VP17

Toxin (Protein)


Gene name relB Uniprot ID U2ZZV8
Locus tag JHT19_RS09310 Protein ID WP_005464459.1
Coordinates 2018045..2018314 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W4CB60
Locus tag JHT19_RS09315 Protein ID WP_005483180.1
Coordinates 2018307..2018561 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHT19_RS09285 (JHT19_09260) 2014207..2014653 - 447 Protein_1801 GNAT family N-acetyltransferase -
JHT19_RS09290 (JHT19_09265) 2014832..2015242 - 411 WP_024701711.1 hypothetical protein -
JHT19_RS09295 (JHT19_09270) 2015323..2016213 - 891 WP_005485669.1 hypothetical protein -
JHT19_RS09300 (JHT19_09280) 2016723..2017523 - 801 WP_159408403.1 IS3 family transposase -
JHT19_RS09305 (JHT19_09285) 2017520..2017828 - 309 WP_005464425.1 transposase -
JHT19_RS09310 (JHT19_09290) 2018045..2018314 - 270 WP_005464459.1 Txe/YoeB family addiction module toxin Toxin
JHT19_RS09315 (JHT19_09295) 2018307..2018561 - 255 WP_005483180.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JHT19_RS09320 (JHT19_09300) 2018664..2018783 - 120 WP_078581129.1 DUF3265 domain-containing protein -
JHT19_RS09325 (JHT19_09305) 2018770..2019144 - 375 WP_025787405.1 hypothetical protein -
JHT19_RS09330 (JHT19_09310) 2019793..2020188 - 396 WP_017449623.1 ACT domain-containing protein -
JHT19_RS09335 (JHT19_09315) 2020342..2020737 - 396 WP_114867630.1 hypothetical protein -
JHT19_RS09340 (JHT19_09320) 2020837..2021757 + 921 WP_010446562.1 IS5-like element ISVa2 family transposase -
JHT19_RS09345 (JHT19_09325) 2021771..2021995 - 225 WP_114867631.1 hypothetical protein -
JHT19_RS09350 (JHT19_09330) 2022144..2022605 - 462 WP_025787408.1 RidA family protein -
JHT19_RS09355 2022641..2022733 - 93 Protein_1815 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vpadF 1966183..2026639 60456
- flank IS/Tn - - 2013732..2013893 161
- inside Integron - - 2014345..2097853 83508


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10614.96 Da        Isoelectric Point: 7.9816

>T187463 WP_005464459.1 NZ_CP068633:c2018314-2018045 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T187463 NZ_CP089849:c159062-158781 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9481.66 Da        Isoelectric Point: 5.0623

>AT187463 WP_005483180.1 NZ_CP068633:c2018561-2018307 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT187463 NZ_CP089849:c159286-159059 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2ZZV8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4CB60

References