Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1834387..1834915 Replicon chromosome
Accession NZ_CP068631
Organism Vibrio parahaemolyticus strain TJ-20

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag JHT10_RS16460 Protein ID WP_005377002.1
Coordinates 1834625..1834915 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag JHT10_RS16455 Protein ID WP_005377003.1
Coordinates 1834387..1834635 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHT10_RS16415 1830186..1830374 - 189 WP_021823297.1 pyridoxamine 5'-phosphate oxidase family protein -
JHT10_RS16425 (JHT10_16405) 1832182..1832472 - 291 WP_005500341.1 YkgJ family cysteine cluster protein -
JHT10_RS16430 (JHT10_16410) 1832739..1833023 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
JHT10_RS16435 (JHT10_16415) 1833020..1833298 + 279 WP_005500338.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
JHT10_RS16440 (JHT10_16420) 1833327..1833416 - 90 WP_072828858.1 DUF3265 domain-containing protein -
JHT10_RS16445 (JHT10_16425) 1833434..1833787 - 354 WP_017449619.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
JHT10_RS16450 (JHT10_16430) 1834244..1834312 - 69 WP_074531725.1 DUF3265 domain-containing protein -
JHT10_RS16455 (JHT10_16435) 1834387..1834635 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JHT10_RS16460 (JHT10_16440) 1834625..1834915 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHT10_RS16465 (JHT10_16445) 1835054..1835413 - 360 WP_029806843.1 hypothetical protein -
JHT10_RS16470 (JHT10_16450) 1835569..1835952 - 384 WP_029806841.1 hypothetical protein -
JHT10_RS16475 (JHT10_16455) 1836108..1836650 - 543 WP_029806840.1 SEC-C metal-binding domain-containing protein -
JHT10_RS16480 (JHT10_16460) 1836725..1836835 - 111 WP_077345731.1 DUF3265 domain-containing protein -
JHT10_RS16485 (JHT10_16465) 1837119..1837208 - 90 WP_077345730.1 DUF3265 domain-containing protein -
JHT10_RS16490 (JHT10_16470) 1837231..1837572 - 342 WP_029807300.1 hypothetical protein -
JHT10_RS16495 1837769..1837957 - 189 Protein_1616 hypothetical protein -
JHT10_RS16500 (JHT10_16475) 1838184..1838696 - 513 WP_029807290.1 hypothetical protein -
JHT10_RS16505 (JHT10_16480) 1839210..1839338 - 129 WP_077345729.1 DUF3265 domain-containing protein -
JHT10_RS16510 1839746..1839874 - 129 WP_089184017.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vpadF 1787820..1874336 86516
- inside Integron - - 1829868..1852111 22243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T187461 WP_005377002.1 NZ_CP068631:1834625-1834915 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T187461 NZ_CP089848:3230509-3231087 [Paralcaligenes sp. KSB-10]
ATGGCCGGATCGTATAGCTACACCGTCATTCTCGACGCCTGTGTTTTGTATCCAGCGCCGTTGCGGGATTTACTGTTGAG
TCTTGCTGAGGCCGACGTATTCCGCGGGCGCTGGACATCATCCATTCACGATGAATGGACCAGAAATGTATTGGCTAAAC
GTCCGGATCTAAAACCTGACACTCTGAATCGTACTGTGGAGCTAATGAATGAGGCCGTCGATGACTGTTTGGTAGAAAAT
TACGAATATCTTATCGACTCTCTGACCTTGCCAGACGAAAATGATCGACATGTTCTCGCGGCAGCTATTGCTGGGCATGC
CGATGCGATAGTTACTTTCAATCTCAAAGATTTTCCTAGCGAGATTGCAAACGCACATGGCCTAGAAATATTGCATCCCG
ATGATTTTCTAGTCGCACAATATGACTTGGCTCCAGTAAGAATGCTAAAGGTCGTCCAAACGCTCCGTGAACGACTCAAA
AATCCACAACGAACCGCACAAGAGCTAATTGCCACATACCTCTCCCAAGGCTTGCCACAAACTTGTAAATTACTGGAAGA
CGCAATTGGATTAATCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT187461 WP_005377003.1 NZ_CP068631:1834387-1834635 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT187461 NZ_CP089848:3230032-3230505 [Paralcaligenes sp. KSB-10]
ATGTCAAACGACCTCGATCTGGATATGGTCCTGGACAATAAAGAAGATGTGGAGCTTGCAAAAGCCGCACAGCGTTGCAT
AGTTAGCGCACTGGATCATTCTAAAGCGATCAATATCGCGATAATTGAAGATGGCGTCGAGCGGCATGATGGATCGCCTC
TACTGCGCTTGCCTCCTAAGGCTTTGCGGCTTATCGCCGACCTGCTTGGCTCATTAGCCCAGGGTAAGGCTGTCGCCATA
ATACCGAAGGAGCTTGACGTTACGACGCAAGAAGCTGCCATGTTTTTGAACGTCTCCCGCCCTTTTCTCGTACGACTGTT
GGAGGACGGCAAGATTCAATATCACAAGGTCGGGACACATAGAAGAATACGCTTTGAGGATGTAGTCAAGTACAAGGAAA
ACAGGCGGAAAATCTCAGAAGCTGCTCTGCAGAAACTAACTGACCAAGCTCAAGAGATGGATATGGGCTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References