Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1413075..1413634 | Replicon | chromosome |
| Accession | NZ_CP068627 | ||
| Organism | Vibrio parahaemolyticus strain LH80 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A347UR22 |
| Locus tag | JHS95_RS07295 | Protein ID | WP_005398411.1 |
| Coordinates | 1413075..1413353 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | JHS95_RS07300 | Protein ID | WP_005398409.1 |
| Coordinates | 1413350..1413634 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JHS95_RS07255 (JHS95_07175) | 1408534..1408623 | + | 90 | WP_075111359.1 | DUF3265 domain-containing protein | - |
| JHS95_RS07260 (JHS95_07180) | 1408651..1409160 | + | 510 | WP_237302066.1 | ClbS/DfsB family four-helix bundle protein | - |
| JHS95_RS07265 (JHS95_07185) | 1409320..1409757 | + | 438 | WP_045956202.1 | hypothetical protein | - |
| JHS95_RS07270 (JHS95_07190) | 1410740..1410829 | + | 90 | WP_072829120.1 | DUF3265 domain-containing protein | - |
| JHS95_RS07275 (JHS95_07195) | 1410970..1411485 | + | 516 | WP_180763555.1 | type VI secretion system amidase effector protein Tae4 | - |
| JHS95_RS07280 | 1411666..1411740 | + | 75 | Protein_1354 | DUF3265 domain-containing protein | - |
| JHS95_RS07285 (JHS95_07200) | 1411838..1412122 | + | 285 | WP_140059252.1 | hypothetical protein | - |
| JHS95_RS07290 (JHS95_07205) | 1412257..1412937 | + | 681 | WP_025510758.1 | hypothetical protein | - |
| JHS95_RS07295 (JHS95_07210) | 1413075..1413353 | - | 279 | WP_005398411.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| JHS95_RS07300 (JHS95_07215) | 1413350..1413634 | - | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| JHS95_RS07305 (JHS95_07220) | 1414595..1414795 | + | 201 | WP_129830217.1 | hypothetical protein | - |
| JHS95_RS07310 (JHS95_07225) | 1414834..1414926 | + | 93 | WP_079749005.1 | DUF3265 domain-containing protein | - |
| JHS95_RS07315 (JHS95_07230) | 1414954..1415469 | + | 516 | WP_140062308.1 | hypothetical protein | - |
| JHS95_RS07320 (JHS95_07235) | 1415605..1416135 | + | 531 | WP_050904921.1 | hypothetical protein | - |
| JHS95_RS07325 (JHS95_07240) | 1416150..1416242 | + | 93 | WP_078555132.1 | DUF3265 domain-containing protein | - |
| JHS95_RS07330 (JHS95_07245) | 1416288..1417865 | - | 1578 | WP_025538704.1 | reverse transcriptase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 | 1205963..1697998 | 492035 | |
| - | inside | Integron | - | - | 1282479..1430131 | 147652 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10891.57 Da Isoelectric Point: 4.3430
>T187459 WP_005398411.1 NZ_CP068627:c1413353-1413075 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T187459 NZ_CP089848:956314-956652 [Paralcaligenes sp. KSB-10]
ATGAGCAAACGCTATATCCCCACGGCCGGCGATATCATCTGGCTGCATTTCGATGTGCCCAAAGGCTCAACCGGCCCCGG
CTACAAGCCCGCGGTCGTGCTCAGTCCTCTTGCCTACAACAAAAAAACTGGGCTAATGATATGTTGCCCCATTACCCCGA
CTATCAAGGGCTATCCGTTCGAAGTCCTGATCGACGCCGAACAGCGCATCGCCGCCCTGTCCGATCAAATCAAAAGCCTG
GATTGGGCAAGCAGCAAAATCAGCCACCAGGGACGCATCAGCTCATCCGAACTGGCCGAGATCCGCGCAAAGCTGCAAGC
ACTCATTTTTAAAGGGTAA
ATGAGCAAACGCTATATCCCCACGGCCGGCGATATCATCTGGCTGCATTTCGATGTGCCCAAAGGCTCAACCGGCCCCGG
CTACAAGCCCGCGGTCGTGCTCAGTCCTCTTGCCTACAACAAAAAAACTGGGCTAATGATATGTTGCCCCATTACCCCGA
CTATCAAGGGCTATCCGTTCGAAGTCCTGATCGACGCCGAACAGCGCATCGCCGCCCTGTCCGATCAAATCAAAAGCCTG
GATTGGGCAAGCAGCAAAATCAGCCACCAGGGACGCATCAGCTCATCCGAACTGGCCGAGATCCGCGCAAAGCTGCAAGC
ACTCATTTTTAAAGGGTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT187459 WP_005398409.1 NZ_CP068627:c1413634-1413350 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT187459 NZ_CP089848:956070-956294 [Paralcaligenes sp. KSB-10]
ATGCGTGGCGTAATTAAAAAATGGGGTAACAGTGCAGCGGTGCGCTTGCCATCGTCGATGATGAAAACACTCAAACTCGA
CCTGGAAGACGTCATCAATATCAGCGTCGAGCATGGCAATATCGTGATCGAGCCCATACGCACCGAAGAATACGTGCTTA
GCCAATTATTGGGCGGAATCAAAGCCAAGAACATACACGCCGAAATCGATTTTGGCGCCGCATAA
ATGCGTGGCGTAATTAAAAAATGGGGTAACAGTGCAGCGGTGCGCTTGCCATCGTCGATGATGAAAACACTCAAACTCGA
CCTGGAAGACGTCATCAATATCAGCGTCGAGCATGGCAATATCGTGATCGAGCCCATACGCACCGAAGAATACGTGCTTA
GCCAATTATTGGGCGGAATCAAAGCCAAGAACATACACGCCGAAATCGATTTTGGCGCCGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR22 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR21 |