Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1402031..1402559 Replicon chromosome
Accession NZ_CP068627
Organism Vibrio parahaemolyticus strain LH80

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag JHS95_RS07210 Protein ID WP_005377002.1
Coordinates 1402031..1402321 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag JHS95_RS07215 Protein ID WP_005377003.1
Coordinates 1402311..1402559 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHS95_RS07165 (JHS95_07095) 1397516..1398070 + 555 WP_237302026.1 hypothetical protein -
JHS95_RS07170 (JHS95_07100) 1398719..1398808 + 90 WP_072829120.1 DUF3265 domain-containing protein -
JHS95_RS07175 (JHS95_07105) 1398829..1399296 + 468 WP_229615329.1 GIY-YIG nuclease family protein -
JHS95_RS07180 (JHS95_07110) 1399337..1399426 + 90 WP_072875472.1 DUF3265 domain-containing protein -
JHS95_RS07185 (JHS95_07115) 1399541..1399798 + 258 WP_069497690.1 hypothetical protein -
JHS95_RS07190 1400801..1400872 + 72 Protein_1336 DUF3265 domain-containing protein -
JHS95_RS07195 (JHS95_07120) 1401186..1401275 + 90 WP_072875472.1 DUF3265 domain-containing protein -
JHS95_RS07200 (JHS95_07125) 1401283..1401600 - 318 WP_025539087.1 CcdB family protein -
JHS95_RS07205 (JHS95_07130) 1401600..1401845 - 246 WP_020838907.1 type II toxin-antitoxin system CcdA family antitoxin -
JHS95_RS07210 (JHS95_07135) 1402031..1402321 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHS95_RS07215 (JHS95_07140) 1402311..1402559 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JHS95_RS07220 (JHS95_07145) 1402634..1402702 + 69 WP_074531725.1 DUF3265 domain-containing protein -
JHS95_RS07225 (JHS95_07150) 1403182..1403274 + 93 WP_079771495.1 DUF3265 domain-containing protein -
JHS95_RS07230 (JHS95_07155) 1403328..1403606 - 279 WP_053340079.1 hypothetical protein -
JHS95_RS07235 (JHS95_07160) 1403596..1405329 - 1734 WP_053340080.1 hypothetical protein -
JHS95_RS07240 (JHS95_07165) 1405582..1406130 + 549 WP_025502382.1 hypothetical protein -
JHS95_RS07245 (JHS95_07170) 1406286..1406678 - 393 WP_237302012.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 1205963..1697998 492035
- inside Integron - - 1282479..1430131 147652


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T187458 WP_005377002.1 NZ_CP068627:c1402321-1402031 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T187458 NZ_CP089799:4608210-4608521 [Salmonella enterica subsp. enterica serovar Kentucky]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT187458 WP_005377003.1 NZ_CP068627:c1402559-1402311 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT187458 NZ_CP089799:4608518-4608964 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References