Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 1375462..1375978 | Replicon | chromosome |
| Accession | NZ_CP068627 | ||
| Organism | Vibrio parahaemolyticus strain LH80 | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | U2ZZV8 |
| Locus tag | JHS95_RS06940 | Protein ID | WP_005464459.1 |
| Coordinates | 1375709..1375978 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | - |
| Locus tag | JHS95_RS06935 | Protein ID | WP_140062282.1 |
| Coordinates | 1375462..1375716 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JHS95_RS06890 (JHS95_06835) | 1370848..1371279 | + | 432 | WP_025510776.1 | hypothetical protein | - |
| JHS95_RS06895 | 1371773..1371885 | + | 113 | Protein_1278 | DUF3265 domain-containing protein | - |
| JHS95_RS06900 (JHS95_06840) | 1371959..1372372 | + | 414 | WP_140346212.1 | VOC family protein | - |
| JHS95_RS06905 (JHS95_06845) | 1372380..1372502 | + | 123 | Protein_1280 | DUF3265 domain-containing protein | - |
| JHS95_RS06910 (JHS95_06850) | 1372544..1372894 | + | 351 | WP_140062286.1 | DUF3147 family protein | - |
| JHS95_RS06915 (JHS95_06855) | 1372926..1373015 | + | 90 | WP_140062301.1 | DUF3265 domain-containing protein | - |
| JHS95_RS06920 | 1373193..1373375 | + | 183 | WP_229617630.1 | hypothetical protein | - |
| JHS95_RS06925 (JHS95_06860) | 1373512..1374150 | + | 639 | WP_140062284.1 | hypothetical protein | - |
| JHS95_RS06930 | 1375309..1375359 | + | 51 | WP_223304363.1 | hypothetical protein | - |
| JHS95_RS06935 (JHS95_06870) | 1375462..1375716 | + | 255 | WP_140062282.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| JHS95_RS06940 (JHS95_06875) | 1375709..1375978 | + | 270 | WP_005464459.1 | Txe/YoeB family addiction module toxin | Toxin |
| JHS95_RS06945 (JHS95_06880) | 1376539..1376631 | + | 93 | WP_079748816.1 | DUF3265 domain-containing protein | - |
| JHS95_RS06950 (JHS95_06885) | 1376660..1377169 | + | 510 | WP_140062281.1 | hypothetical protein | - |
| JHS95_RS06955 (JHS95_06890) | 1377184..1377276 | + | 93 | WP_071936822.1 | DUF3265 domain-containing protein | - |
| JHS95_RS06960 (JHS95_06895) | 1377592..1378703 | + | 1112 | WP_237302016.1 | IS3 family transposase | - |
| JHS95_RS06965 (JHS95_06900) | 1378767..1379312 | + | 546 | WP_237302063.1 | ion channel | - |
| JHS95_RS06970 (JHS95_06905) | 1379446..1380156 | + | 711 | WP_140062280.1 | hypothetical protein | - |
| JHS95_RS06975 (JHS95_06910) | 1380176..1380268 | + | 93 | WP_004748931.1 | DUF3265 domain-containing protein | - |
| JHS95_RS06980 (JHS95_06915) | 1380305..1380937 | + | 633 | WP_021823046.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 | 1205963..1697998 | 492035 | |
| - | inside | Integron | - | - | 1282479..1430131 | 147652 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10614.96 Da Isoelectric Point: 7.9816
>T187457 WP_005464459.1 NZ_CP068627:1375709-1375978 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY
Download Length: 270 bp
>T187457 NZ_CP089799:c4606977-4606666 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
Antitoxin
Download Length: 85 a.a. Molecular weight: 9439.58 Da Isoelectric Point: 5.0481
>AT187457 WP_140062282.1 NZ_CP068627:1375462-1375716 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARD
LIDE
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTARD
LIDE
Download Length: 255 bp
>AT187457 NZ_CP089799:c4606665-4606375 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTAAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGCTCACCGACAGGGCCAGCCAAAGCATTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTAAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGCTCACCGACAGGGCCAGCCAAAGCATTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|