Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1356438..1356966 Replicon chromosome
Accession NZ_CP068627
Organism Vibrio parahaemolyticus strain LH80

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag JHS95_RS06745 Protein ID WP_005377002.1
Coordinates 1356438..1356728 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag JHS95_RS06750 Protein ID WP_005377003.1
Coordinates 1356718..1356966 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHS95_RS06680 (JHS95_06635) 1351573..1351695 + 123 WP_237302111.1 DUF3265 domain-containing protein -
JHS95_RS06685 (JHS95_06640) 1351800..1352057 + 258 WP_237302051.1 hypothetical protein -
JHS95_RS06690 (JHS95_06645) 1352436..1352558 + 123 WP_083151209.1 DUF3265 domain-containing protein -
JHS95_RS06695 (JHS95_06650) 1352695..1352934 + 240 WP_079883267.1 hypothetical protein -
JHS95_RS06700 (JHS95_06655) 1353160..1353378 + 219 WP_021453865.1 DUF6500 family protein -
JHS95_RS06705 (JHS95_06660) 1353400..1353522 + 123 Protein_1240 DUF3265 domain-containing protein -
JHS95_RS06710 (JHS95_06665) 1353492..1353848 + 357 WP_237302122.1 hypothetical protein -
JHS95_RS06715 (JHS95_06670) 1354052..1354549 + 498 WP_025555145.1 DinB family protein -
JHS95_RS06720 (JHS95_06675) 1354691..1355227 + 537 WP_029826930.1 nucleotidyltransferase family protein -
JHS95_RS06725 (JHS95_06680) 1355362..1355793 + 432 WP_029841611.1 hypothetical protein -
JHS95_RS06730 (JHS95_06685) 1355808..1355900 + 93 WP_074050554.1 DUF3265 domain-containing protein -
JHS95_RS06735 (JHS95_06690) 1355930..1356298 + 369 WP_237302112.1 VOC family protein -
JHS95_RS06740 1356291..1356365 + 75 Protein_1247 DUF3265 domain-containing protein -
JHS95_RS06745 (JHS95_06695) 1356438..1356728 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHS95_RS06750 (JHS95_06700) 1356718..1356966 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JHS95_RS06755 (JHS95_06705) 1357041..1357109 + 69 WP_074531725.1 DUF3265 domain-containing protein -
JHS95_RS06760 (JHS95_06710) 1357170..1357481 + 312 WP_025787446.1 antibiotic biosynthesis monooxygenase -
JHS95_RS06765 (JHS95_06715) 1357499..1357588 + 90 WP_079400562.1 DUF3265 domain-containing protein -
JHS95_RS06770 (JHS95_06720) 1357951..1358043 + 93 WP_079741409.1 DUF3265 domain-containing protein -
JHS95_RS06775 (JHS95_06725) 1358577..1359161 + 585 WP_237302052.1 hypothetical protein -
JHS95_RS06780 (JHS95_06730) 1359307..1359723 + 417 WP_237302053.1 hypothetical protein -
JHS95_RS06785 (JHS95_06735) 1359720..1360448 + 729 WP_237302054.1 hypothetical protein -
JHS95_RS06790 (JHS95_06740) 1360914..1361003 + 90 WP_072828858.1 DUF3265 domain-containing protein -
JHS95_RS06795 (JHS95_06745) 1361031..1361450 + 420 WP_237302055.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 1205963..1697998 492035
- inside Integron - - 1282479..1430131 147652


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T187456 WP_005377002.1 NZ_CP068627:c1356728-1356438 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T187456 NZ_CP089799:c4290289-4289798 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT187456 WP_005377003.1 NZ_CP068627:c1356966-1356718 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT187456 NZ_CP089799:c4290579-4290286 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References