Detailed information of TA system TA187455

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1339890..1340437
• Replicon: chromosome
• Accession: NZ_CP068627
• Organism: Vibrio parahaemolyticus strain LH80

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JHS95_RS06580
• Protein ID: WP_237302043.1
• Coordinates: 1340135..1340437 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3A269
• Locus tag: JHS95_RS06575
• Protein ID: WP_005448240.1
• Coordinates: 1339890..1340147 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHS95_RS06525 (JHS95_06480)	1334974..1335342	+	369	WP_024701877.1	VOC family protein	-
JHS95_RS06530 (JHS95_06485)	1335374..1335463	+	90	WP_237302110.1	DUF3265 domain-containing protein	-
JHS95_RS06535 (JHS95_06490)	1335516..1336355	+	840	WP_102619191.1	DUF4365 domain-containing protein	-
JHS95_RS06540 (JHS95_06495)	1336507..1336983	+	477	WP_025559909.1	GNAT family N-acetyltransferase	-
JHS95_RS06545 (JHS95_06500)	1336980..1337102	+	123	WP_081008321.1	DUF3265 domain-containing protein	-
JHS95_RS06550 (JHS95_06505)	1337130..1337606	+	477	WP_237302041.1	GNAT family N-acetyltransferase	-
JHS95_RS06555	1337603..1337680	+	78	Protein_1210	DUF3265 domain-containing protein	-
JHS95_RS06560 (JHS95_06515)	1337757..1338734	+	978	WP_237302042.1	hypothetical protein	-
JHS95_RS06565 (JHS95_06520)	1338734..1338847	+	114	WP_079855764.1	DUF3265 domain-containing protein	-
JHS95_RS06570 (JHS95_06525)	1338886..1339695	+	810	WP_005433999.1	nucleotide-binding protein	-
JHS95_RS06575 (JHS95_06530)	1339890..1340147	+	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JHS95_RS06580 (JHS95_06535)	1340135..1340437	+	303	WP_237302043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JHS95_RS06585 (JHS95_06540)	1340474..1340566	+	93	WP_237302044.1	DUF3265 domain-containing protein	-
JHS95_RS06590 (JHS95_06545)	1340665..1340955	+	291	WP_140276582.1	YkgJ family cysteine cluster protein	-
JHS95_RS06595 (JHS95_06550)	1341208..1341675	+	468	WP_031857408.1	cold shock domain-containing protein	-
JHS95_RS06600 (JHS95_06555)	1341704..1341793	+	90	WP_072875472.1	DUF3265 domain-containing protein	-
JHS95_RS06605 (JHS95_06560)	1342342..1342737	-	396	WP_170967275.1	hypothetical protein	-
JHS95_RS06610 (JHS95_06565)	1342866..1342955	+	90	WP_074190212.1	DUF3265 domain-containing protein	-
JHS95_RS06615 (JHS95_06570)	1343088..1343312	+	225	WP_017051481.1	hypothetical protein	-
JHS95_RS06620 (JHS95_06575)	1343394..1343720	+	327	WP_237302045.1	hypothetical protein	-
JHS95_RS06625 (JHS95_06580)	1343847..1344638	+	792	WP_237302046.1	Cthe_2314 family HEPN domain-containing protein	-
JHS95_RS06630 (JHS95_06585)	1344884..1345264	+	381	WP_140095620.1	hypothetical protein	-
JHS95_RS06635 (JHS95_06590)	1345309..1345401	+	93	WP_140095622.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611	1205963..1697998	492035
	-	inside	Integron	-	-	1282479..1430131	147652

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11686.55 Da
• Isoelectric Point: 4.8838

>T187455 WP_237302043.1 NZ_CP068627:1340135-1340437 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIADYIALENIVAAKQLVQTIFSKVERLETFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRTERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T187455 NZ_CP089799:4151839-4152255 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCTGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9606.10 Da
• Isoelectric Point: 6.7269

>AT187455 WP_005448240.1 NZ_CP068627:1339890-1340147 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT187455 NZ_CP089799:4151612-4151842 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Structures

Antitoxin

• AlphaFold DB: A0A432DGX8