Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1331739..1332286 Replicon chromosome
Accession NZ_CP068627
Organism Vibrio parahaemolyticus strain LH80

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JHS95_RS06480 Protein ID WP_237302038.1
Coordinates 1331984..1332286 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JHS95_RS06475 Protein ID WP_237302037.1
Coordinates 1331739..1331996 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHS95_RS06445 (JHS95_06405) 1328779..1329069 - 291 WP_038208214.1 type II toxin-antitoxin system RelE/ParE family toxin -
JHS95_RS06450 (JHS95_06410) 1329059..1329307 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JHS95_RS06455 (JHS95_06415) 1329382..1329450 + 69 WP_074531725.1 DUF3265 domain-containing protein -
JHS95_RS06460 (JHS95_06420) 1329500..1330186 + 687 WP_140265738.1 DUF4336 domain-containing protein -
JHS95_RS06465 (JHS95_06425) 1330359..1330985 + 627 WP_237302035.1 LysE family translocator -
JHS95_RS06470 (JHS95_06430) 1330991..1331104 + 114 WP_237302036.1 DUF3265 domain-containing protein -
JHS95_RS06475 (JHS95_06435) 1331739..1331996 + 258 WP_237302037.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JHS95_RS06480 (JHS95_06440) 1331984..1332286 + 303 WP_237302038.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHS95_RS06485 (JHS95_06445) 1332325..1332414 + 90 WP_086375053.1 DUF3265 domain-containing protein -
JHS95_RS06490 (JHS95_06450) 1332494..1332880 + 387 WP_272910821.1 GFA family protein -
JHS95_RS06495 (JHS95_06455) 1333043..1333681 + 639 WP_237302039.1 hypothetical protein -
JHS95_RS06500 1333647..1333793 + 147 WP_237302040.1 DUF3265 domain-containing protein -
JHS95_RS06505 (JHS95_06460) 1333822..1334175 + 354 WP_023623407.1 hypothetical protein -
JHS95_RS06510 (JHS95_06465) 1334205..1334297 + 93 WP_071652176.1 DUF3265 domain-containing protein -
JHS95_RS06515 (JHS95_06470) 1334325..1334831 + 507 WP_023623426.1 hypothetical protein -
JHS95_RS06520 (JHS95_06475) 1334852..1334944 + 93 WP_228070214.1 DUF3265 domain-containing protein -
JHS95_RS06525 (JHS95_06480) 1334974..1335342 + 369 WP_024701877.1 VOC family protein -
JHS95_RS06530 (JHS95_06485) 1335374..1335463 + 90 WP_237302110.1 DUF3265 domain-containing protein -
JHS95_RS06535 (JHS95_06490) 1335516..1336355 + 840 WP_102619191.1 DUF4365 domain-containing protein -
JHS95_RS06540 (JHS95_06495) 1336507..1336983 + 477 WP_025559909.1 GNAT family N-acetyltransferase -
JHS95_RS06545 (JHS95_06500) 1336980..1337102 + 123 WP_081008321.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 1205963..1697998 492035
- inside Integron - - 1282479..1430131 147652


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11640.53 Da        Isoelectric Point: 4.8951

>T187454 WP_237302038.1 NZ_CP068627:1331984-1332286 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQAIFSKVERLESFPESGRIPPELEHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T187454 NZ_CP089799:3618412-3618669 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9636.12 Da        Isoelectric Point: 6.7269

>AT187454 WP_237302037.1 NZ_CP068627:1331739-1331996 [Vibrio parahaemolyticus]
MKVELVTSLKRQTTKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT187454 NZ_CP089799:c3618587-3618255 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References