Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 1315395..1315940 Replicon chromosome
Accession NZ_CP068627
Organism Vibrio parahaemolyticus strain LH80

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag JHS95_RS06330 Protein ID WP_025559895.1
Coordinates 1315395..1315691 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag JHS95_RS06335 Protein ID WP_023585842.1
Coordinates 1315698..1315940 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHS95_RS06275 (JHS95_06245) 1310421..1310939 + 519 WP_237302023.1 GNAT family N-acetyltransferase -
JHS95_RS06280 (JHS95_06250) 1310915..1311046 + 132 WP_237302024.1 DUF3265 domain-containing protein -
JHS95_RS06285 (JHS95_06255) 1311076..1311462 + 387 WP_237302025.1 hypothetical protein -
JHS95_RS06290 (JHS95_06260) 1311609..1311959 + 351 WP_038152015.1 hypothetical protein -
JHS95_RS06295 (JHS95_06265) 1311989..1312078 + 90 WP_079866498.1 DUF3265 domain-containing protein -
JHS95_RS06300 (JHS95_06270) 1312138..1312692 + 555 WP_237302026.1 hypothetical protein -
JHS95_RS06305 (JHS95_06275) 1312849..1313481 + 633 WP_237302027.1 hypothetical protein -
JHS95_RS06310 (JHS95_06280) 1313727..1313909 + 183 WP_237302028.1 hypothetical protein -
JHS95_RS06315 (JHS95_06285) 1314100..1314474 + 375 WP_237302029.1 hypothetical protein -
JHS95_RS06320 1314478..1314587 + 110 Protein_1163 DUF3265 domain-containing protein -
JHS95_RS06325 (JHS95_06290) 1314625..1315224 + 600 WP_025527501.1 cytochrome c oxidase assembly factor Coa1 family protein -
JHS95_RS06330 (JHS95_06295) 1315395..1315691 - 297 WP_025559895.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHS95_RS06335 (JHS95_06300) 1315698..1315940 - 243 WP_023585842.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JHS95_RS06340 (JHS95_06305) 1316067..1316144 + 78 WP_078235893.1 DUF3265 domain-containing protein -
JHS95_RS06345 (JHS95_06310) 1316655..1316744 + 90 WP_077281693.1 DUF3265 domain-containing protein -
JHS95_RS06350 (JHS95_06315) 1316788..1317204 + 417 WP_237302030.1 VOC family protein -
JHS95_RS06355 1317238..1317315 + 78 WP_079884017.1 DUF3265 domain-containing protein -
JHS95_RS06360 (JHS95_06325) 1317639..1317764 + 126 WP_237302031.1 DUF3265 domain-containing protein -
JHS95_RS06365 (JHS95_06330) 1318123..1318245 + 123 WP_080262734.1 DUF3265 domain-containing protein -
JHS95_RS06370 (JHS95_06335) 1318750..1320027 + 1278 WP_025506479.1 hypothetical protein -
JHS95_RS06375 (JHS95_06340) 1320133..1320483 + 351 WP_038152015.1 hypothetical protein -
JHS95_RS06380 (JHS95_06345) 1320513..1320602 + 90 WP_079866498.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 1205963..1697998 492035
- inside Integron - - 1282479..1430131 147652


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-54)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11305.96 Da        Isoelectric Point: 9.3813

>T187452 WP_025559895.1 NZ_CP068627:c1315691-1315395 [Vibrio parahaemolyticus]
MQKNKYKLSKLAQAHLLKIKNYTVNNFSEMQWRNYKDTLLTGFQMLADNPEVGRSCDDIYPNGFHFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Download         Length: 297 bp

>T187452 NZ_CP089799:2427729-2428013 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8917.15 Da        Isoelectric Point: 5.1006

>AT187452 WP_023585842.1 NZ_CP068627:c1315940-1315698 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLKHCFESAKKDLAQGNVVDGEDFLSAL

Download         Length: 243 bp

>AT187452 NZ_CP089799:2427491-2427739 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References