Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 1309116..1309681 Replicon chromosome
Accession NZ_CP068627
Organism Vibrio parahaemolyticus strain LH80

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JHS95_RS06255 Protein ID WP_025539049.1
Coordinates 1309394..1309681 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JHS95_RS06250 Protein ID WP_237302021.1
Coordinates 1309116..1309397 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHS95_RS06210 1304125..1304388 - 264 WP_237302106.1 hypothetical protein -
JHS95_RS06215 (JHS95_06190) 1304514..1304645 + 132 WP_237302018.1 DUF3265 domain-containing protein -
JHS95_RS25215 1304875..1305009 + 135 WP_259556213.1 hypothetical protein -
JHS95_RS06220 (JHS95_06195) 1305080..1305190 + 111 WP_147289580.1 DUF3265 domain-containing protein -
JHS95_RS06225 (JHS95_06200) 1305220..1306083 + 864 WP_237302019.1 HNH endonuclease signature motif containing protein -
JHS95_RS06230 1306098..1306190 + 93 WP_237302020.1 DUF3265 domain-containing protein -
JHS95_RS06235 (JHS95_06205) 1306798..1307328 + 531 WP_025559857.1 hypothetical protein -
JHS95_RS06240 1308390..1308479 + 90 WP_237302107.1 DUF3265 domain-containing protein -
JHS95_RS06245 1308936..1309025 + 90 WP_237302108.1 DUF3265 domain-containing protein -
JHS95_RS06250 (JHS95_06220) 1309116..1309397 + 282 WP_237302021.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JHS95_RS06255 (JHS95_06225) 1309394..1309681 + 288 WP_025539049.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHS95_RS06260 (JHS95_06230) 1309691..1309801 + 111 WP_171055932.1 DUF3265 domain-containing protein -
JHS95_RS06265 (JHS95_06235) 1309836..1310282 + 447 WP_237302022.1 GNAT family N-acetyltransferase -
JHS95_RS06270 (JHS95_06240) 1310279..1310389 + 111 WP_071652529.1 DUF3265 domain-containing protein -
JHS95_RS06275 (JHS95_06245) 1310421..1310939 + 519 WP_237302023.1 GNAT family N-acetyltransferase -
JHS95_RS06280 (JHS95_06250) 1310915..1311046 + 132 WP_237302024.1 DUF3265 domain-containing protein -
JHS95_RS06285 (JHS95_06255) 1311076..1311462 + 387 WP_237302025.1 hypothetical protein -
JHS95_RS06290 (JHS95_06260) 1311609..1311959 + 351 WP_038152015.1 hypothetical protein -
JHS95_RS06295 (JHS95_06265) 1311989..1312078 + 90 WP_079866498.1 DUF3265 domain-containing protein -
JHS95_RS06300 (JHS95_06270) 1312138..1312692 + 555 WP_237302026.1 hypothetical protein -
JHS95_RS06305 (JHS95_06275) 1312849..1313481 + 633 WP_237302027.1 hypothetical protein -
JHS95_RS06310 (JHS95_06280) 1313727..1313909 + 183 WP_237302028.1 hypothetical protein -
JHS95_RS06315 (JHS95_06285) 1314100..1314474 + 375 WP_237302029.1 hypothetical protein -
JHS95_RS06320 1314478..1314587 + 110 Protein_1163 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 1205963..1697998 492035
- inside Integron - - 1282479..1430131 147652


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11034.70 Da        Isoelectric Point: 5.1098

>T187451 WP_025539049.1 NZ_CP068627:1309394-1309681 [Vibrio parahaemolyticus]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNEVFDKTELLGNMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILTEDDV

Download         Length: 288 bp

>T187451 NZ_CP089799:2061420-2061523 [Salmonella enterica subsp. enterica serovar Kentucky]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10380.83 Da        Isoelectric Point: 5.1548

>AT187451 WP_237302021.1 NZ_CP068627:1309116-1309397 [Vibrio parahaemolyticus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEIRTAEAQLASGLGVSN
EDARAQVLGRINK

Download         Length: 282 bp

>AT187451 NZ_CP089799:c2061525-2061382 [Salmonella enterica subsp. enterica serovar Kentucky]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References