Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4940668..4941184 Replicon chromosome
Accession NZ_CP068614
Organism Klebsiella pneumoniae strain 42362

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JMZ78_RS24530 Protein ID WP_002886902.1
Coordinates 4940668..4940952 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMZ78_RS24535 Protein ID WP_002886901.1
Coordinates 4940942..4941184 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMZ78_RS24505 4936152..4936460 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
JMZ78_RS24510 4936545..4936718 + 174 WP_002886906.1 hypothetical protein -
JMZ78_RS24515 4936721..4937464 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMZ78_RS24520 4937821..4939959 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JMZ78_RS24525 4940200..4940664 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMZ78_RS24530 4940668..4940952 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMZ78_RS24535 4940942..4941184 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMZ78_RS24540 4941262..4943172 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMZ78_RS24545 4943195..4944349 - 1155 WP_002886900.1 lactonase family protein -
JMZ78_RS24550 4944415..4945155 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T187423 WP_002886902.1 NZ_CP068614:c4940952-4940668 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T187423 NZ_CP089797:195438-195923 [Salmonella enterica subsp. enterica serovar Kentucky]
GTGGGACATGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCAACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGAAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT187423 WP_002886901.1 NZ_CP068614:c4941184-4940942 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT187423 NZ_CP089797:195163-195450 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References