Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5276596..5277221 Replicon chromosome
Accession NZ_CP068610
Organism Klebsiella pneumoniae strain 45706

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JMZ75_RS26080 Protein ID WP_002882817.1
Coordinates 5276596..5276979 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMZ75_RS26085 Protein ID WP_004150355.1
Coordinates 5276979..5277221 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMZ75_RS26065 5273962..5274864 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JMZ75_RS26070 5274861..5275496 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMZ75_RS26075 5275493..5276422 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JMZ75_RS26080 5276596..5276979 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JMZ75_RS26085 5276979..5277221 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMZ75_RS26090 5277426..5278343 + 918 WP_002882812.1 alpha/beta hydrolase -
JMZ75_RS26095 5278357..5279298 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMZ75_RS26100 5279343..5279780 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMZ75_RS26105 5279777..5280637 - 861 WP_002882807.1 virulence factor BrkB family protein -
JMZ75_RS26110 5280631..5281230 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T187406 WP_002882817.1 NZ_CP068610:c5276979-5276596 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T187406 NZ_CP089794:3618399-3618656 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT187406 WP_004150355.1 NZ_CP068610:c5277221-5276979 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT187406 NZ_CP089794:c3618574-3618242 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References