Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4828615..4829131 Replicon chromosome
Accession NZ_CP068602
Organism Klebsiella pneumoniae strain 59493

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JMZ77_RS23790 Protein ID WP_002886902.1
Coordinates 4828615..4828899 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMZ77_RS23795 Protein ID WP_002886901.1
Coordinates 4828889..4829131 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMZ77_RS23765 4824099..4824407 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
JMZ77_RS23770 4824492..4824665 + 174 WP_002886906.1 hypothetical protein -
JMZ77_RS23775 4824668..4825411 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMZ77_RS23780 4825768..4827906 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JMZ77_RS23785 4828147..4828611 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMZ77_RS23790 4828615..4828899 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMZ77_RS23795 4828889..4829131 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMZ77_RS23800 4829209..4831119 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMZ77_RS23805 4831142..4832296 - 1155 WP_002886900.1 lactonase family protein -
JMZ77_RS23810 4832362..4833102 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T187383 WP_002886902.1 NZ_CP068602:c4828899-4828615 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T187383 NZ_CP089791:4151103-4151519 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCTGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT187383 WP_002886901.1 NZ_CP068602:c4829131-4828889 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT187383 NZ_CP089791:4150876-4151106 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References