Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 873178..873835 Replicon chromosome
Accession NZ_CP068602
Organism Klebsiella pneumoniae strain 59493

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMZ77_RS04415 Protein ID WP_002916310.1
Coordinates 873425..873835 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMZ77_RS04410 Protein ID WP_002916312.1
Coordinates 873178..873444 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMZ77_RS04385 868334..869767 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JMZ77_RS04390 869886..870614 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMZ77_RS04395 870664..870975 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
JMZ77_RS04400 871139..871798 + 660 WP_002916317.1 hemolysin III family protein -
JMZ77_RS04405 871949..872932 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JMZ77_RS04410 873178..873444 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMZ77_RS04415 873425..873835 + 411 WP_002916310.1 protein YgfX Toxin
JMZ77_RS04420 873842..874363 - 522 WP_002916308.1 flavodoxin FldB -
JMZ77_RS04425 874464..875360 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMZ77_RS04430 875383..876096 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMZ77_RS04435 876102..877835 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T187371 WP_002916310.1 NZ_CP068602:873425-873835 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T187371 NZ_CP089790:4151335-4151751 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCTGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT187371 WP_002916312.1 NZ_CP068602:873178-873444 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT187371 NZ_CP089790:4151108-4151338 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References