Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3303786..3304391 Replicon chromosome
Accession NZ_CP068595
Organism Paenibacillus sonchi strain LMG 24727

Toxin (Protein)


Gene name mazF Uniprot ID A0A0E4H7G2
Locus tag JI735_RS15010 Protein ID WP_019913013.1
Coordinates 3304041..3304391 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JI735_RS15005 Protein ID WP_174469047.1
Coordinates 3303786..3304037 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI735_RS14985 3299978..3300814 + 837 WP_039836293.1 methyl-accepting chemotaxis protein -
JI735_RS14990 3300842..3301015 + 174 WP_202677525.1 hypothetical protein -
JI735_RS14995 3301053..3302138 + 1086 WP_039836292.1 outer membrane lipoprotein carrier protein LolA -
JI735_RS15000 3302361..3303542 + 1182 WP_039836290.1 alanine racemase -
JI735_RS15005 3303786..3304037 + 252 WP_174469047.1 ribbon-helix-helix protein, CopG family Antitoxin
JI735_RS15010 3304041..3304391 + 351 WP_019913013.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JI735_RS15015 3304804..3306107 + 1304 Protein_2900 extracellular solute-binding protein -
JI735_RS15020 3306214..3307098 + 885 WP_039836289.1 sugar ABC transporter permease -
JI735_RS15025 3307101..3307928 + 828 WP_039836288.1 carbohydrate ABC transporter permease -
JI735_RS15030 3307962..3308780 + 819 WP_039836287.1 carbohydrate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-35)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12749.67 Da        Isoelectric Point: 4.8265

>T187367 WP_019913013.1 NZ_CP068595:3304041-3304391 [Paenibacillus sonchi]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQV
RTIDKQRLTDKITHLDDETMKLVDDSLQISLGLIDF

Download         Length: 351 bp

>T187367 NZ_CP089790:2060528-2060631 [Salmonella enterica subsp. enterica serovar Kentucky]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9487.94 Da        Isoelectric Point: 5.1051

>AT187367 WP_174469047.1 NZ_CP068595:3303786-3304037 [Paenibacillus sonchi]
MISLPDHLLQEVDGIVQLENSNRSELIRQAMKLYLSERRKRTIRDSMQRGYMEMAKINLTMACEAFLAEEDADSTLGRLV
SGV

Download         Length: 252 bp

>AT187367 NZ_CP089790:c2060633-2060490 [Salmonella enterica subsp. enterica serovar Kentucky]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E4H7G2

Antitoxin

Source ID Structure

References