Detailed information of TA system TA187360

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3992445..3993099
• Replicon: chromosome
• Accession: NZ_CP068591
• Organism: Escherichia coli strain EF7-18-58

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: F4NJ21
• Locus tag: JMY44_RS18880
• Protein ID: WP_000244772.1
• Coordinates: 3992445..3992852 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: JMY44_RS18885
• Protein ID: WP_063100142.1
• Coordinates: 3992833..3993099 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMY44_RS18860	3988402..3990135	-	1734	WP_000813215.1	single-stranded-DNA-specific exonuclease RecJ	-
JMY44_RS18865	3990141..3990851	-	711	WP_000715214.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
JMY44_RS18870	3990876..3991772	-	897	WP_000806638.1	site-specific tyrosine recombinase XerD	-
JMY44_RS18875	3991884..3992405	+	522	WP_001055874.1	flavodoxin FldB	-
JMY44_RS18880	3992445..3992852	-	408	WP_000244772.1	protein YgfX	Toxin
JMY44_RS18885	3992833..3993099	-	267	WP_063100142.1	FAD assembly factor SdhE	Antitoxin
JMY44_RS18890	3993342..3994322	+	981	WP_000886062.1	tRNA-modifying protein YgfZ	-
JMY44_RS18895	3994399..3995058	-	660	WP_000250274.1	hemolysin III family protein	-
JMY44_RS18900	3995222..3995533	-	312	WP_001182944.1	N(4)-acetylcytidine aminohydrolase	-
JMY44_RS18905	3995578..3997011	+	1434	WP_001363803.1	6-phospho-beta-glucosidase BglA	-
JMY44_RS18910	3997068..3997811	-	744	WP_000951964.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16048.02 Da
• Isoelectric Point: 11.2511

>T187360 WP_000244772.1 NZ_CP068591:c3992852-3992445 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T187360 NZ_CP089789:c4291038-4290547 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10548.07 Da
• Isoelectric Point: 5.1599

>AT187360 WP_063100142.1 NZ_CP068591:c3993099-3992833 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFNRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT187360 NZ_CP089789:c4291328-4291035 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• AlphaFold DB: A0A0E0XYB4