Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3035620..3036451 Replicon chromosome
Accession NZ_CP068591
Organism Escherichia coli strain EF7-18-58

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JMY44_RS14455 Protein ID WP_000854814.1
Coordinates 3036077..3036451 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag JMY44_RS14450 Protein ID WP_001285585.1
Coordinates 3035620..3035988 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMY44_RS14415 3030852..3031922 + 1071 WP_000102664.1 patatin-like phospholipase family protein -
JMY44_RS14420 3032058..3032741 + 684 WP_023147547.1 hypothetical protein -
JMY44_RS14425 3032757..3033167 + 411 WP_000846713.1 hypothetical protein -
JMY44_RS14430 3033388..3034209 + 822 WP_001234530.1 DUF945 domain-containing protein -
JMY44_RS14435 3034291..3034770 + 480 WP_000860076.1 antirestriction protein -
JMY44_RS14440 3034786..3035262 + 477 WP_001186773.1 RadC family protein -
JMY44_RS14445 3035325..3035546 + 222 WP_000692323.1 DUF987 domain-containing protein -
JMY44_RS14450 3035620..3035988 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JMY44_RS14455 3036077..3036451 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JMY44_RS14460 3036448..3036642 + 195 WP_000988600.1 hypothetical protein -
JMY44_RS14465 3036655..3036768 + 114 WP_001161660.1 DUF957 domain-containing protein -
JMY44_RS14470 3037057..3037185 - 129 Protein_2815 transposase domain-containing protein -
JMY44_RS14475 3037257..3037439 + 183 WP_001016348.1 hypothetical protein -
JMY44_RS14480 3037540..3037869 - 330 WP_000450409.1 DUF496 family protein -
JMY44_RS14485 3038041..3039099 - 1059 WP_029364112.1 FUSC family protein -
JMY44_RS14490 3039297..3039770 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
JMY44_RS14495 3039889..3041055 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T187356 WP_000854814.1 NZ_CP068591:3036077-3036451 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T187356 NZ_CP089789:2428575-2428859 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT187356 WP_001285585.1 NZ_CP068591:3035620-3035988 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT187356 NZ_CP089789:2428337-2428585 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References