Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2415697..2416335 Replicon chromosome
Accession NZ_CP068591
Organism Escherichia coli strain EF7-18-58

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JMY44_RS11435 Protein ID WP_000813794.1
Coordinates 2415697..2415873 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMY44_RS11440 Protein ID WP_001270286.1
Coordinates 2415919..2416335 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMY44_RS11415 2411316..2412530 - 1215 WP_001349372.1 BenE family transporter YdcO -
JMY44_RS11420 2412583..2413119 + 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
JMY44_RS11425 2413192..2415153 + 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JMY44_RS11430 2415245..2415475 - 231 WP_000494244.1 YncJ family protein -
JMY44_RS11435 2415697..2415873 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JMY44_RS11440 2415919..2416335 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JMY44_RS11445 2416414..2417820 + 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
JMY44_RS11450 2418065..2419210 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
JMY44_RS11455 2419228..2420241 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
JMY44_RS11460 2420242..2421183 + 942 WP_001251319.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2410011..2411276 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T187346 WP_000813794.1 NZ_CP068591:2415697-2415873 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T187346 NZ_CP089788:c2824925-2824822 [Salmonella enterica subsp. enterica serovar Kentucky]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT187346 WP_001270286.1 NZ_CP068591:2415919-2416335 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT187346 NZ_CP089788:2824820-2824963 [Salmonella enterica subsp. enterica serovar Kentucky]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References