Detailed information of TA system TA187326

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 924939..925468
• Replicon: chromosome
• Accession: NZ_CP068576
• Organism: Staphylococcus equorum strain KS1030

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: K7S376
• Locus tag: JL104_RS04335
• Protein ID: WP_002511418.1
• Coordinates: 925106..925468 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: J9GY23
• Locus tag: JL104_RS04330
• Protein ID: WP_002507108.1
• Coordinates: 924939..925109 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JL104_RS04305	920690..921169	+	480	WP_002507103.1	PH domain-containing protein	-
JL104_RS04310	921162..922667	+	1506	WP_202809226.1	PH domain-containing protein	-
JL104_RS04315	922660..923196	+	537	WP_002507105.1	PH domain-containing protein	-
JL104_RS04320	923229..923579	+	351	WP_002507106.1	holo-ACP synthase	-
JL104_RS04325	923703..924851	+	1149	WP_002507107.1	alanine racemase	-
JL104_RS04330	924939..925109	+	171	WP_002507108.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
JL104_RS04335	925106..925468	+	363	WP_002511418.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
JL104_RS04340	925833..926834	+	1002	WP_002507111.1	PP2C family protein-serine/threonine phosphatase	-
JL104_RS04345	926914..927240	+	327	WP_002511417.1	anti-sigma factor antagonist	-
JL104_RS04350	927242..927724	+	483	WP_002507113.1	anti-sigma B factor RsbW	-
JL104_RS04355	927699..928469	+	771	WP_002507114.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-112)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13432.59 Da
• Isoelectric Point: 10.2178

>T187326 WP_002511418.1 NZ_CP068576:925106-925468 [Staphylococcus equorum]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSESKMKEVNVAIDISLGLHNVRNSKS

Nucleotide

• Length: 363 bp

>T187326 NZ_CP089781:c2962759-2962436 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6305.92 Da
• Isoelectric Point: 4.0121

>AT187326 WP_002507108.1 NZ_CP068576:924939-925109 [Staphylococcus equorum]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYLSSKNNNE

Nucleotide

• Length: 171 bp

>AT187326 NZ_CP089781:c2963084-2962839 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Structures

Toxin

• AlphaFold DB: K7S376

Antitoxin

• AlphaFold DB: J9GY23