Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4215158..4215815 Replicon chromosome
Accession NZ_CP068572
Organism Klebsiella pneumoniae strain IR1251

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JJV77_RS20670 Protein ID WP_002916310.1
Coordinates 4215158..4215568 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JJV77_RS20675 Protein ID WP_002916312.1
Coordinates 4215549..4215815 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJV77_RS20650 4211158..4212891 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
JJV77_RS20655 4212897..4213610 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JJV77_RS20660 4213633..4214529 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JJV77_RS20665 4214630..4215151 + 522 WP_002916308.1 flavodoxin FldB -
JJV77_RS20670 4215158..4215568 - 411 WP_002916310.1 protein YgfX Toxin
JJV77_RS20675 4215549..4215815 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JJV77_RS20680 4216061..4217044 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JJV77_RS20685 4217195..4217854 - 660 WP_002916317.1 hemolysin III family protein -
JJV77_RS20690 4218018..4218329 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
JJV77_RS20695 4218379..4219107 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JJV77_RS20700 4219226..4220659 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T187316 WP_002916310.1 NZ_CP068572:c4215568-4215158 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T187316 NZ_CP089781:2242954-2243352 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT187316 WP_002916312.1 NZ_CP068572:c4215815-4215549 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT187316 NZ_CP089781:2242726-2242953 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References