Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1064789..1065408 Replicon chromosome
Accession NZ_CP068572
Organism Klebsiella pneumoniae strain IR1251

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JJV77_RS05155 Protein ID WP_002892050.1
Coordinates 1064789..1065007 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JJV77_RS05160 Protein ID WP_002892066.1
Coordinates 1065034..1065408 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJV77_RS05120 1060836..1061099 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
JJV77_RS05125 1061099..1061239 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JJV77_RS05130 1061236..1061934 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
JJV77_RS05135 1062035..1063486 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JJV77_RS05140 1063461..1063931 - 471 WP_002892026.1 YlaC family protein -
JJV77_RS05145 1063952..1064092 + 141 WP_004147370.1 hypothetical protein -
JJV77_RS05150 1064064..1064630 - 567 WP_002892030.1 maltose O-acetyltransferase -
JJV77_RS05155 1064789..1065007 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JJV77_RS05160 1065034..1065408 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JJV77_RS05165 1065894..1069040 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JJV77_RS05170 1069063..1070256 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T187306 WP_002892050.1 NZ_CP068572:c1065007-1064789 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T187306 NZ_CP089781:1682509-1682826 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT187306 WP_002892066.1 NZ_CP068572:c1065408-1065034 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT187306 NZ_CP089781:1682210-1682512 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References