Detailed information of TA system TA187300

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3449719..3450344
• Replicon: chromosome
• Accession: NZ_CP068562
• Organism: Morganella morganii strain FAM24681

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A0A2RCL2
• Locus tag: JC794_RS16605
• Protein ID: WP_024474604.1
• Coordinates: 3450141..3450344 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: JC794_RS16600
• Protein ID: WP_046893178.1
• Coordinates: 3449719..3450078 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC794_RS16590 (JC794_16590)	3444773..3445966	+	1194	WP_107678490.1	efflux RND transporter periplasmic adaptor subunit	-
JC794_RS16595 (JC794_16595)	3445981..3449157	+	3177	WP_107678491.1	efflux RND transporter permease subunit	-
JC794_RS16600 (JC794_16600)	3449719..3450078	+	360	WP_046893178.1	Hha toxicity modulator TomB	Antitoxin
JC794_RS16605 (JC794_16605)	3450141..3450344	+	204	WP_024474604.1	HHA domain-containing protein	Toxin
JC794_RS16615 (JC794_16615)	3451222..3452085	+	864	WP_054424719.1	acyl-CoA thioesterase II	-
JC794_RS16620 (JC794_16620)	3452147..3453436	-	1290	WP_107678658.1	ammonium transporter AmtB	-
JC794_RS16625 (JC794_16625)	3453456..3453794	-	339	WP_107678492.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-113)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8073.39 Da
• Isoelectric Point: 6.9770

>T187300 WP_024474604.1 NZ_CP068562:3450141-3450344 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Nucleotide

• Length: 204 bp

>T187300 NZ_CP089781:c1228300-1227989 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACACCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13840.57 Da
• Isoelectric Point: 4.2870

>AT187300 WP_046893178.1 NZ_CP068562:3449719-3450078 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNFWVNDLASDSNLKLNELLGYIADVTWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Nucleotide

• Length: 360 bp

>AT187300 NZ_CP089781:c1228620-1228300 [Mycobacterium tuberculosis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Structures

Toxin

• AlphaFold DB: A0A0A2RCL2