Detailed information of TA system TA187261

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 3931383..3932580
• Replicon: chromosome
• Accession: NZ_CP068551
• Organism: Pseudomonas khazarica strain ODT-83

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A653AZT1
• Locus tag: JLK41_RS18545
• Protein ID: WP_037049289.1
• Coordinates: 3931383..3932135 (-)
• Length: 251 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JLK41_RS18550
• Protein ID: WP_210389560.1
• Coordinates: 3932209..3932580 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JLK41_RS18520 (JLK41_18520)	3927289..3928206	+	918	WP_210389558.1	alpha/beta fold hydrolase	-
JLK41_RS18525 (JLK41_18525)	3928203..3929093	+	891	WP_210389559.1	metal-dependent hydrolase	-
JLK41_RS18530 (JLK41_18530)	3929151..3930512	-	1362	WP_167494366.1	DNA recombination protein RmuC	-
JLK41_RS18535 (JLK41_18535)	3930693..3930944	-	252	WP_037049286.1	hypothetical protein	-
JLK41_RS18540 (JLK41_18540)	3930943..3931239	+	297	WP_152489372.1	hypothetical protein	-
JLK41_RS18545 (JLK41_18545)	3931383..3932135	-	753	WP_037049289.1	RES family NAD+ phosphorylase	Toxin
JLK41_RS18550 (JLK41_18550)	3932209..3932580	-	372	WP_210389560.1	XRE family transcriptional regulator	Antitoxin
JLK41_RS18555 (JLK41_18555)	3932715..3935276	+	2562	WP_210389561.1	YdbH domain-containing protein	-
JLK41_RS18560 (JLK41_18560)	3935281..3935472	+	192	WP_037049298.1	YnbE family lipoprotein	-
JLK41_RS18565 (JLK41_18565)	3935554..3935892	+	339	WP_210389562.1	YdbL family protein	-
JLK41_RS18570 (JLK41_18570)	3935964..3936290	-	327	WP_037049304.1	Grx4 family monothiol glutaredoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (62-207)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (8-68)

Sequences

Toxin

Protein

• Length: 251 a.a.
• Molecular weight: 28164.20 Da
• Isoelectric Point: 8.2660

>T187261 WP_037049289.1 NZ_CP068551:c3932135-3931383 [Pseudomonas khazarica]
MDIWQQCAGERQVRPLRGKLLRMVESQAQVATSQLVDNLAEQALLEDLLENSKPPLPEAAEPLHYLLKTPFRYPPLRWGS
RFGTVHEPSLFYAAQHLQTAMAEAAYYRFVLWNGMLSPPPSGRILSEHSTFEARYRVERGIQLQLPPFDAHAALLAHPSD
YSVAQRLGAAMRAADIQAFEYRSARCPAGGSNVALYVPQAFAEKRPRNLTAWLCETTGDYVAFKPAQVPGQPRLFRWEQF
LVQGQLPHPA

Nucleotide

• Length: 753 bp

>T187261 NZ_CP089780:2805267-2805692 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGCGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13607.77 Da
• Isoelectric Point: 10.6605

>AT187261 WP_210389560.1 NZ_CP068551:c3932580-3932209 [Pseudomonas khazarica]
MSALIRSQPDADAVLAKALLNTREQLGLTQQELADIVGVHRSAISRWGEHGGLRPQSKTGELALLLIRAYRALFALFGGN
LQDMRHFLRTENRHLAGVPLQQMGQVQGLVRVVEYLDAIRGKV

Nucleotide

• Length: 372 bp

>AT187261 NZ_CP089780:2805040-2805261 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Structures

Toxin

• AlphaFold DB: A0A653AZT1