Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 3920038..3921438 Replicon chromosome
Accession NZ_CP068551
Organism Pseudomonas khazarica strain ODT-83

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JLK41_RS18500 Protein ID WP_152489368.1
Coordinates 3920869..3921438 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JLK41_RS18495 Protein ID WP_037049257.1
Coordinates 3920038..3920862 (-) Length 275 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLK41_RS18480 (JLK41_18480) 3916923..3917828 - 906 WP_037049248.1 GIDE domain-containing protein -
JLK41_RS18485 (JLK41_18485) 3917839..3918411 - 573 WP_037049251.1 LemA family protein -
JLK41_RS18490 (JLK41_18490) 3918602..3919939 + 1338 WP_037049254.1 imelysin family protein -
JLK41_RS18495 (JLK41_18495) 3920038..3920862 - 825 WP_037049257.1 AraC family transcriptional regulator Antitoxin
JLK41_RS18500 (JLK41_18500) 3920869..3921438 - 570 WP_152489368.1 GNAT family protein Toxin
JLK41_RS18505 (JLK41_18505) 3921644..3925132 + 3489 WP_210389556.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
JLK41_RS18510 (JLK41_18510) 3925239..3926186 + 948 WP_210389557.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3925239..3926186 947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(14-146)

Antitoxin

DNA binding HTH domain, AraC-type

(193-270)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21470.63 Da        Isoelectric Point: 8.0493

>T187260 WP_152489368.1 NZ_CP068551:c3921438-3920869 [Pseudomonas khazarica]
MFKPQLVTLQRGALRLEPLSDADIPALVALAESNRDELLYMSGTQRLDWYRSALADLREQRALPFVVRLGDELVGTTRFA
EFMNTLPACEIGWTWLDRSQHGTGLNGTIKYLMLRHAFDNWGMVRVQLKTAGSNLRSQRAIEKLGAVREGLLRNHRRLAD
GRLDDTVLYSMTDLEWPAVREALEARFGA

Download         Length: 570 bp

>T187260 NZ_CP089780:c2402794-2402477 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 275 a.a.        Molecular weight: 30600.82 Da        Isoelectric Point: 7.8397

>AT187260 WP_037049257.1 NZ_CP068551:c3920862-3920038 [Pseudomonas khazarica]
MESREQTRFWQASALCGVELLQARYLQQRFAPHVHEGFVFTVIEHGAQRFRHRGSDHLAPQGSMVLINPDEVHTGSKAHD
DGWRYRGFYPDNAQVLGALQELGLARSGMPSFAVSVLDDPCLHTAFLQLHRLLEDGAEALQQQLAWREAILLLFQHHGRV
GEAAAPGREPWAVSCAKQMLAEQLLEPPSLEELAAAVNLSPFHFARVFRRATGLPPHAWLKQRRLEQARALLRSGCSAIG
VATQLGFADQSHLSRQFKQVYGVSPGEYRKACLS

Download         Length: 825 bp

>AT187260 NZ_CP089780:c2403006-2402791 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References