Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 1680020..1680605 Replicon chromosome
Accession NZ_CP068551
Organism Pseudomonas khazarica strain ODT-83

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag JLK41_RS07825 Protein ID WP_150608788.1
Coordinates 1680303..1680605 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag JLK41_RS07820 Protein ID WP_037048838.1
Coordinates 1680020..1680310 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLK41_RS07795 (JLK41_07795) 1675767..1676438 + 672 WP_210390709.1 hypothetical protein -
JLK41_RS07800 (JLK41_07800) 1676477..1677370 - 894 WP_210390710.1 LysR family transcriptional regulator -
JLK41_RS07805 (JLK41_07805) 1677466..1678632 + 1167 WP_037048844.1 MFS transporter -
JLK41_RS07810 (JLK41_07810) 1678797..1679282 - 486 WP_210390711.1 LysE family translocator -
JLK41_RS07815 (JLK41_07815) 1679426..1679914 + 489 WP_134676284.1 Lrp/AsnC family transcriptional regulator -
JLK41_RS07820 (JLK41_07820) 1680020..1680310 - 291 WP_037048838.1 putative addiction module antidote protein Antitoxin
JLK41_RS07825 (JLK41_07825) 1680303..1680605 - 303 WP_150608788.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JLK41_RS07830 (JLK41_07830) 1680821..1684864 + 4044 WP_210390712.1 ATP-dependent RNA helicase HrpA -
JLK41_RS07835 (JLK41_07835) 1684942..1685205 + 264 WP_037048833.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(6-94)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11431.14 Da        Isoelectric Point: 10.3872

>T187258 WP_150608788.1 NZ_CP068551:c1680605-1680303 [Pseudomonas khazarica]
MRKIESATFRNWLKKLKDDTGKARIVARINRLMEGLPGDVAPVGHGVSELRIHYGPGYRVYFHQQGDTLVILLCAGDKGS
QRRDIEAAQQILQTWRKRDD

Download         Length: 303 bp

>T187258 NZ_CP089780:2321092-2321502 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10399.85 Da        Isoelectric Point: 5.1023

>AT187258 WP_037048838.1 NZ_CP068551:c1680310-1680020 [Pseudomonas khazarica]
MTETFSDFDPAEYLTSPAAIAEFMSDALETGDAGYIAKALGVVARAKGMTELARETGLSREQLYRSFSEHGNPTLKTMLA
VMKALGIEMSARPHAR

Download         Length: 291 bp

>AT187258 NZ_CP089780:2320866-2321099 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References