Detailed information of TA system TA187255

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 1921780..1922367
• Replicon: chromosome
• Accession: NZ_CP068547
• Organism: Tamlana sp. s12

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: JJL45_RS08345
• Protein ID: WP_068602916.1
• Coordinates: 1922068..1922367 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JJL45_RS08340
• Protein ID: WP_068602917.1
• Coordinates: 1921780..1922064 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJL45_RS08320	1917500..1918669	-	1170	WP_068602921.1	DUF4105 domain-containing protein	-
JJL45_RS08325	1918666..1919763	-	1098	WP_068602920.1	PorV/PorQ family protein	-
JJL45_RS08330	1920064..1920813	+	750	WP_068602919.1	CDP-alcohol phosphatidyltransferase family protein	-
JJL45_RS08335	1920819..1921703	+	885	WP_068602918.1	DUF808 domain-containing protein	-
JJL45_RS08340	1921780..1922064	-	285	WP_068602917.1	putative addiction module antidote protein	Antitoxin
JJL45_RS08345	1922068..1922367	-	300	WP_068602916.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JJL45_RS08350	1922639..1922944	+	306	WP_202664382.1	nucleotidyltransferase domain-containing protein	-
JJL45_RS08355	1922913..1923251	+	339	WP_068602915.1	DUF86 domain-containing protein	-
JJL45_RS08360	1923759..1924499	-	741	WP_067150611.1	LPS export ABC transporter ATP-binding protein	-
JJL45_RS08365	1924574..1924921	-	348	WP_068602914.1	carboxymuconolactone decarboxylase family protein	-
JJL45_RS08370	1924911..1925738	-	828	WP_068602913.1	twin-arginine translocase subunit TatC	-
JJL45_RS08375	1925738..1926703	-	966	WP_068602912.1	KpsF/GutQ family sugar-phosphate isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1921780..1931604	9824

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-92)

Antitoxin

• Uncharacterized protein HI1420 (3-89)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11900.96 Da
• Isoelectric Point: 10.4831

>T187255 WP_068602916.1 NZ_CP068547:c1922367-1922068 [Tamlana sp. s12]
MFFIEKTNEFDKWFRKLKDLKAKAKILFRIQKLETDEHFGDCKIVGDGIREMRINFAKGYRVYFKEKDRKIIVLLIGGDK
STQQKDITKAKEIWRNLNN

Nucleotide

• Length: 300 bp

>T187255 NZ_CP089780:c2225619-2225059 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10115.66 Da
• Isoelectric Point: 5.0508

>AT187255 WP_068602917.1 NZ_CP068547:c1922064-1921780 [Tamlana sp. s12]
MGTSRFEIADYLESKEMIAEYLNTVLEEGTNADIINAIGHIAKAIGMTKISEETGLSRPSLYKALSDGAKPQFATIMKVL
KAIGGQIQINPISS

Nucleotide

• Length: 285 bp

>AT187255 NZ_CP089780:c2225957-2225616 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA