Detailed information of TA system TA187254

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 468322..468863
• Replicon: chromosome
• Accession: NZ_CP068547
• Organism: Tamlana sp. s12

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JJL45_RS01980
• Protein ID: WP_068601032.1
• Coordinates: 468561..468863 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: JJL45_RS01975
• Protein ID: WP_068601034.1
• Coordinates: 468322..468564 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJL45_RS01955	464211..465191	+	981	WP_068601039.1	PD-(D/E)XK motif protein	-
JJL45_RS01960	465184..467571	+	2388	WP_068601037.1	AIPR family protein	-
JJL45_RS01965	467616..467867	-	252	WP_068601036.1	hypothetical protein	-
JJL45_RS01970	467961..468104	-	144	WP_202664217.1	hypothetical protein	-
JJL45_RS01975	468322..468564	+	243	WP_068601034.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
JJL45_RS01980	468561..468863	+	303	WP_068601032.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JJL45_RS01985	468989..470947	-	1959	WP_068601029.1	YgiQ family radical SAM protein	-
JJL45_RS01990	471083..472054	-	972	WP_202664218.1	lipase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 12222.24 Da
• Isoelectric Point: 10.0321

>T187254 WP_068601032.1 NZ_CP068547:468561-468863 [Tamlana sp. s12]
MSKNKYRISKQAIDDLNDIWVYTFHKWSKEQADRYYDLIIGEIEFIADNYLIGKSAEQTRKNYRVTKIKSHLIFYRKVEN
EIVEIVRILHIRMDIKKRLI

Nucleotide

• Length: 303 bp

>T187254 NZ_CP089780:c2218152-2217733 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9284.48 Da
• Isoelectric Point: 6.7299

>AT187254 WP_068601034.1 NZ_CP068547:468322-468564 [Tamlana sp. s12]
MGKNTSISLGNHFEEFIREEVKSGRYGSVSEVIRSALRLLEREEKKERELIKALEVGENSGFIENFDPKQNLTDLHRKHL

Nucleotide

• Length: 243 bp

>AT187254 NZ_CP089780:c2218421-2218161 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA